Ankylosing Spondylitis
Conditions
Keywords
Ankylosing spondylitis, complete blood count, inflammation
Brief summary
In this study, the aim was to investigate the relationship between SII and other laboratory parameters with disease activity in AS patients and to discuss its usability in the follow-up and treatment process.
Detailed description
This study aimed to investigate the relationship between the systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and disease activity and functional status in patients with ankylosing spondylitis (AS). A cross-sectional clinical study was conducted, and a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics were included in the study. Demographic data, disease duration, age at symptom onset, and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), red blood cell distribution width (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. NLR and PLR values were calculated. The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. We investigated all of these parameters and disease activity scores. Disease activity was assessed with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), spinal mobility with the Bath Ankylosing Spondylitis Metrology Index (BASMI), and functional status with the Bath Ankylosing Spondylitis Functional Index (BASFI). In addition, during the routine follow-ups of patients, requested blood tests were examined, and platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), RDW (red blood distribution width), CRP, and ESR values will be recorded. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammation index (SII) were calculated
Interventions
OTHERNo intervention
No intervention
Sponsors
Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients between the ages of 18 and 65 who have been diagnosed with Ankylosing Spondylitis according to the Modified New York Criteria, have applied to the Istanbul Physical Medicine and Rehabilitation Training and Research Hospital outpatient clinic on the specified dates, meet the
Exclusion criteria
, and have complete blood count, CRP, and ESR values in their hospital records.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Systemic Immune Inflammation Index (SII) | through study completion, an average of 1 month | The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. |
| Neutrophil-to-lymphocyte ratio (NLR) | through study completion, an average of 1 month | NLR is a ratio between the absolute neutrophil count and absolute lymphocyte count. |
| Platelet to-lymphocyte ratio (PLR) | through study completion, an average of 1 month | PLR is a ratio between the absolute platelet count and absolute lymphocyte count. |
| Mean platelet volume (MPV) | through study completion, an average of 1 month | MPV blood test measures the average size of patient's platelets |
| Red blood cell distribution width (RDW) | through study completion, an average of 1 month | A red cell distribution width (RDW) test measures the differences in the volume and size of the red blood cells (erythrocytes). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate | through study completion, an average of 1 month | it helps to evaluate disease activity of AS patients by used to esr |
| C-reactive protein | through study completion, an average of 1 month | C-reactive protein (CRP) is a protein made by the liver. The level of CRP increases when there's inflammation in the body. |
| Ankylosing Spondylitis Disease Activity Score with c-reactive protein | through study completion, an average of 1 month | it helps to evaluate disease activity of AS patients by used to crp |
| Erythrocyte sedimentation rate | through study completion, an average of 1 month | The erythrocyte sedimentation rate (sedimentation rate, sed rate, or ESR for short) is a commonly performed hematology test that may indicate and monitor an increase in inflammatory activity within the body caused by one or more conditions such as autoimmune disease, infections, or tumors |
| The Bath Ankylosing Spondylitis Disease Activity Index | through study completion, an average of 1 month | The index indicates that disease activity of AS patients. Higher scores indicate that higher activity |
| The Bath Ankylosing Spondylitis Functional Index | through study completion, an average of 1 month | The index helps to evaluate disease activity of AS patients. High scores indicate that worse functional status. |
| The Bath Ankylosing Spondylitis Metrology Index | through study completion, an average of 1 month | The index helps to evaluate spinal mobility of AS patients. Higher scores indicate more limited mobility. |
Countries
Turkey (Türkiye)
Outcome results
None listed