Inflammation, Oxidative Stress
Conditions
Keywords
Metabolic syndrome, periodontitis, interleukin-20
Brief summary
Metabolic syndrome and periodontitis are diseases that lower the quality of life and their incidence rates are increasing. Since both of these diseases are associated with systemic inflammation and insulin resistance, they may be comorbid. The aim of this study was to evaluate the effect of interleukin-20 (IL-20) on periodontal destruction in individuals with metabolic syndrome while considering the relationship between metabolic syndrome and periodontitis. This study included a total of 80 individuals who were systemically and periodontally healthy (CG, n=20), were systemically healthy and had periodontitis (PG, n=20), had metabolic syndrome and were periodontally healthy (MG, n=20), or had both metabolic syndrome and periodontitis (MPG, n=20). Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses.
Interventions
OTHERGingival crevicular fluid (GCF) and serum samples
Gingival crevicular fluid (GCF) and serum samples were collected from all participants for biochemical analyses
Sponsors
Recep Tayyip Erdogan University
Recep Tayyip Erdogan University Training and Research Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Study groups were created based on the guidelines of the 2017 Classification of Periodontal Diseases and the 2005 Metabolic Syndrome Diagnostic Criteria of the Endocrinology and Metabolic Society of Turkey Inclusion Criteria: * all participants were required to have at least 20 teeth and be between the ages of 20 and 65 years
Exclusion criteria
* Smokers, patients who had used antibiotics or anti-inflammatory and antioxidant drugs in the last 6 months, patients who were pregnant or lactating, those who had cancer or autoimmune diseases, and those who had undergone any periodontal treatment in the last 6 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| concentration of gingival crevicular fluid (GCF) parameters | 1 year | interleukin-20, RANKL, OPG values evaluated in GCF. |
| concentration of serum parameters | 1 year | interleukin-20, RANKL, OPG, MMP-8, TOS, TAS values evaluated in serum |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| value of periodontal clinical parameters | 1 year | plaque index, gingival index, bleeding on probing, Clinical attachment loss, probing pocket depth |
| value of patients' clinical metabolic syndrome parameters | 1 year | Body mass index (BMI), abdominal circumference, and HbA1c |
Countries
Turkey (Türkiye)
Outcome results
None listed