SANS, Spaceflight Associated Neuro-Ocular Syndrome
Conditions
Keywords
SANS, Spaceflight Associated Neuro-Ocular Syndrome, Optical Coherence Tomography Angiography, OCTA, Space, Astronaut
Brief summary
The goal of this study is to understand the impact of space travel on the eyes. Space flight impacts numerous aspects of ocular anatomy and physiology. Current hypotheses are based on pressure changes within and around the optic nerve. Retinal and choroid blood drainage may be affected by microgravity associated cerebrospinal fluid pressure changes. Recently, a new imaging modality, Optical Coherence Tomography Angiography (OCTA), has been able to reveal micro vascular changes in the retina and choroid. To date, no microgravity ocular imaging tests have been published using OCTA. In this study the researchers aim to describe microgravity circadian choroidal and retinal vasculature using multimodal imaging including OCTA to better understand space associated ocular changes.
Interventions
None listed
Sponsors
University of Central Florida
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- astronauts in the AX1/Rakia mission, which was scheduled for space flight in late March 2022.
Exclusion criteria
* adults unable to consent * individuals who are not yet adults (infants, children, teenagers) - * pregnant women * prisoners.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To examine early changes in ocular physiology following exposure to microgravity and asses these changes as risk factor for Spaceflight Associated Neuro-Ocular Syndrome (SANS). | 4 months |
| Asses early changes in ocular physiology as risk factor for Spaceflight Associated Neuro-Ocular Syndrome (SANS). | 4 months |
Countries
United States
Outcome results
None listed