Intraoperative Hypotension
Conditions
Brief summary
This study is a randomized, controlled trial. A total of 92 patients will be randomized to receive sufentanil or remifentanil during extracranial-intracranial bypass surgery.
Interventions
DRUGSufentanil
Induction: sufentanil TCI 0.3 ng/ml Maintenance: sufentanil TCI 0.05-0.5 ng/ml
DRUGRemifentanil
Induction: remifentanil TCI 3 ng/ml Maintenance: remifentanil TCI 0.5-5 ng/ml
Sponsors
Seoul National University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who undergo elective extracranial-intracranial bypass surgery * American Society of Anesthesiologists grade 1,2,3 * Age \> 18 years old
Exclusion criteria
* Refuse to participate to the study * American Society of Anesthesiologists grade 4 * Body Mass Index \< 18.5 kg/m2 or \> 35 kg/m2 * Allergic history of opioid * pregnant * MAO Inhibitor user * Severe respiratory insufficiency
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative hypotension | During surgery | MAP \< 80 mmHg |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inotropic requirements | During surgery | cumulative doses of inotropics during surgery |
| Incidence of bradycardia | During surgery | heart rate \< 40/min |
| Incidence of tachycardia | During surgery | heart rate \> 100/min |
| Maximum systolic blood pressure | During surgery | maximal systolic blood pressure |
| Minimum systolic blood pressure | During surgery | minimal systolic blood pressure |
Countries
South Korea
Contacts
Primary ContactChang-Hoon Koo
Outcome results
None listed