Periodontitis
Conditions
Brief summary
Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic inflammatory disorders. IL-20 has a significant role in the regulation of osteoclastogenesis and osteoblastogenesis. The aim of this study was to evaluate the effect of IL-20 on periodontal destruction. In the study, a total of 60 participants were included, 30 of whom were systemically and periodontally healthy (control group) and 30 of whom were systemically healthy and had periodontitis (periodontitis group). GCF and serum samples were collected from the participants for biochemical analysis. ELISA method was used to determine IL-20, TNF-α, IL1β/IL-10, RANKL/OPG and MMP8 levels
Interventions
OTHERbiochemical analysis
GCF and serum samples were collected from the participants for biochemical analysis.
Sponsors
Recep Tayyip Erdogan University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* The following criteria were required for inclusion: being systemically healthy, not smoking, not using antibiotics or systemic corticosteroids within the previous three months, not being pregnant or nursing, not having a chronic inflammatory disease, not receiving periodontal therapy within the previous six months, and possessing at least 20 teeth
Exclusion criteria
* smoking, using antibiotics or systemic corticosteroids within the previous three months, pregnant, receiving periodontal therapy within the previous six months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| concentration of biochemical findings in gingival crevicular fluid (GCF) | june 2022-june 2023 | IL-20, RANKL, OPG and RANKL/OPG values eveluated in GCF |
| concentration of biochemical findings in serum | 1 year | IL-20, RANKL, OPG, RANKL/OPG, MMP-8, TNF-α, IL-1β, IL-10 and IL-1β/IL-10 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| value of periodontal clinical parameters | 1 year | plaque index (PI) (Silness & Löe), gingival index (GI) (Silness & Löe) and bleeding on probing index (BOP) of all natural teeth of the patients |
| value of periodontal clinical parameters were measured in mm | 1 year | probing pocket depth (PPD), clinical attachment loss (CAL) of all natural teeth of the patients |
Countries
Turkey (Türkiye)
Outcome results
None listed