Cognitive Impairment, Parkinson Disease
Conditions
Keywords
Parkinson Disease, Cognitive Impairment, Deep brain stimulation, Transcranial magnetic stimulation
Brief summary
This study intends to apply structural and functional brain network neuroimaging techniques combined with image post-processing methods to explore the differences in brain network changes in PD patients with cognitive impairment after DBS or TMS.
Detailed description
A variety of post-processing methods (VBM, SPM, CAT, LEAD-DBS, etc.) were used to analyze structural brain network images (sMRI, DTI) and functional brain network images (rs-fMRI, PET) based on connectomics, and combined with the changes of clinical symptoms before and after treatment. To study the mechanism of the influence of neural regulation on brain network, and further analyze how DBS and TMS improve the cognitive symptoms of PD patients from the perspective of brain connectomics, so as to explore the occurrence and development of Parkinson's disease with cognitive impairment and the possible improvement mechanism.According to the individual differences in clinical symptoms of different PD patients, better stimulation sites and the best brain network are sought to further guide the surgical plan, so as to obtain the best clinical treatment effect.
Interventions
DEVICEDeep Brain Stimulation(DBS) and Transcranial Magnetic Stimulation(TMS)
We observed the changes in cognitive function of patients before and after different brain stimulation treatments, and further compared the effects of different brain stimulation treatments on cognitive function of PD patients and the related mechanisms according to whether DBS surgery was performed or TMS therapy was given only according to the surgical indications.
Sponsors
Tianjin Huanhu Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 75 Years
Healthy volunteers
No
Inclusion criteria
1\. The clinical diagnosis of PD is consistent with the United Kingdom Parkinson's Disease Society Brain Bank criteria, with disease duration over 5 years, acute levodopa motor response ≥30%, and indication for STN-DBS.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Montreal Cognitive Rating Scale(MoCA) | December 2023 to December 2026 | The Montreal Cognitive Rating Scale was used to assess the overall cognitive status of patients before and after treatment |
| verbal fluency test (VF) | December 2023 to December 2026 | VF test was used to assess frontal executive function and related language function |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the third part of the Unified Parkinson's Disease Rating Scale (UPDRS III) | December 2023 to December 2026 | Measures motor symptoms and Higher scores indicate more severe impairment in motor function |
Countries
China
Contacts
Primary ContactZhao Guangrui, doctor
Backup ContactFeng Keke, doctor
Outcome results
None listed