Urinary; Sepsis
Conditions
Brief summary
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. For clinical operationalization, organ dysfunction can be represented by an increase in the Sequential Organ Failure Assessment (SOFA) score of 2 points or more, which is associated with an in-hospital mortality greater than 10%. pancreatic stone protein has been studied as biomarker of sepsis and results suggests that it has higher diagnostic performance. The main objective of this study is to identify ability of pancreatic stone protein (PSP) as a new biomarker for diagnosis of urosepsis in Intensive Care Units comparison to other biomarkers and its role as a prognostic marker for mortality
Interventions
DIAGNOSTIC_TESTpancreatic stone protein PSP measurement
Blood samples will be collected for biomarker (PCT, CRP, and PSP) measurements in admission and 24 hours, 72 hours from admission and patients will be followed until death or discharge from the ICU or for 30 days, whichever occurred.
Sponsors
Ain Shams University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult ill patients at the ICU aged more than 18 years old who at risk of urosepsis. * Both males and females.
Exclusion criteria
* \- Age less than 18 years. * Patients with a clinical diagnosis of sepsis at admission. * Critically ill septic patients with a diagnosis other than urosepsis. * Critically ill patients who were diagnosed to have urosepsis outside Ain Shams university intensive care and transferred to it. * Malignant tumor patients. * Uremic patients undergoing dialysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PSP ability to detect urinary sepsis | measurements from admission and patients will be followed until death or discharge from or for 30 days whichever occurred the ICU | time course of PSP serum levels above normal range 20-50ng/ml in absence or presence of infection. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PSP ability to predict prognosis of sepsis in ICU. | measurements from admission and patients will be followed until death or discharge from or for 30 days whichever occurred the ICU | value of serial serum PSP levels from admission in ICU to predict infection severity and complications. |
Outcome results
None listed