Cognitive Disorder, Deafness
Conditions
Keywords
Cognitive Disorder, Deafness
Brief summary
Age-related hearing loss (ARHL), like neurodegenerative diseases, appears insidiously with age. As major public health issues, they are nonetheless under-diagnosed because the presence of one can hinder the objectification of the other. The CogAudio project aims to detect early and in an ambulatory mode in a memory centre a speech perception disorder in noise thanks to the VRB test in patients weakened by cognitive disorders.
Interventions
DIAGNOSTIC_TESTVRB test
V1 (inclusion) : VRB test for detecting speech comprehension disorders in noise. V2 (3 months) : all patients ( independent of the result of the VRB test) will be invited to attend a hearing test within 3 months in order to confirm the diagnosis of deafness by means of a tone audiometry and an ENT medical consultation.
Sponsors
University Hospital, Lille
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient with mild to moderate cognitive impairment, with an MMSE score ≥15/30 * Patient mastering the French language * Patient who has given written consent to participate in the trial * Socially insured patient * Patient willing to comply with all study procedures and duration * Patient accompanied by a study partner
Exclusion criteria
* Medical history of diagnosed deafness, fitted or not * History of progressive otological pathology or presence of tympanic obstruction (\>1/3 of the surface of the eardrum) * History of unstabilized psychiatric pathology * Major visual impairment (Age-Related Macular Degeneration AMD...) * Established diagnosis of major language disorders (Primary Progressive Aphasia APP...) * Major under legal protection measure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ability of the VRB test to detect deafness in patients over 50 with mild to moderate cognitive impairment. | 3 months | Area under the ROC (receiver operating characteristic) curve of the VRB test for hearing loss screening. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To assess the diagnostic values of the VRB threshold associated with a disorder of speech comprehension in noise defined in the general population to screen for deafness in patients over 50 years of age with mild to moderate cognitive impairment. | 3 months or 12 months | Sensitivity, specificity, negative and positive predictive values of the pathological threshold defined in the general population (\>3 BSR ) for hearing loss screening (as defined in the primary endpoint) |
| correlation between the hearing loss and the auditory discomfort (complaint) expressed by the patient and that observed by the caregiver | 3 months or 12 months | Hearing loss is defined by the VRB test score. The auditory complaint expressed by the patient is defined by the score on the HHIE-S questionnaire completed by the patient himself; the auditory complaint noted by the entourage is defined by the score on the adapted HHIE-S questionnaire completed by the caregiver present at the consultation at M0. |
| Frequency of patients with hearing aids at 12 months. | 3 months or 12 months | Frequency of patients with hearing aids at 12 months from inclusion |
| Evolution of the cognitive and functional profile at 12 months between patients with deafness and patients without deafness. | 3 months or 12 months | Variation in scores between M0 and M12 on HAD neuropsychological and speech therapy test. |
| To assess the correlation between an objective cortical marker of selective attention (long latency evoked potentials: P300 wave amplitude; patients' ability to discriminate sounds in silence), and subjects' performance in tone audiometry in silence | 3 months or 12 months | Amplitude and latency of the P300 wave; Tone audiometry score in silence. |
Countries
France
Contacts
Primary ContactPascaline Cassagnaud
Backup ContactJuliette Bochu
Outcome results
None listed