Waldenstrom Macroglobulinemia
Conditions
Brief summary
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in Waldenström's Macroglobulinemia patients, using optical coherence tomography angiography.
Detailed description
Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. The optical coherence tomography angiography represents a novel and noninvasive diagnostic technique that allows a detailed and quantitative analysis of retinal and choriocapillary vascular features. The study evaluates the changes in optical coherence tomography angiography features in Waldenstrom macroglobulinemia, elaborating these data with artificial intelligence.
Interventions
None listed
Sponsors
Federico II University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* age older than 18 years * diagnosis of Waldenstrom Macroglobulinemia * absence of previous ocular surgery and congenital eye diseases. * absence of errors of refraction * absence of lens opacities * absence of low-quality OCT and OCTA images
Exclusion criteria
* • age younger than 18 years * previous ocular surgery and congenital eye diseases * errors of refraction * lens opacities * low-quality OCT and OCTA images
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The measurements of retinal and choriocapillary vessel density in Waldenstrom Macroglobulinemia patients. | up to three months | The parameters analyzed by optical coherence tomography angiography were: retinal and choriocapillary vessel density matched with clinical parameters resulted from the artificial pancreas device |
Countries
Italy
Outcome results
None listed