Coronary Vasospasm, Coronary Microvascular Dysfunction, Non-Obstructive Coronary Atherosclerosis
Conditions
Brief summary
The goal of this registry is to collect data on patients referred for clinically indicated coronary vasomotor function test (CFT) and answer different questions on prevalence, safety and outcomes. The registry is observational. Patients receive yearly online questionnaires on their anginal complaints for 5 years after their CFT.
Interventions
DIAGNOSTIC_TESTCoronary Function Test
All participants are referred for a clinically indicated coronary function test
All participants that consent will receive yearly followup questionnaires for 5 years after their initial consent
Sponsors
UMC Utrecht
Catharina Ziekenhuis Eindhoven
Maasstad Hospital
VieCuri Medical Centre
Frisius Medisch Centrum
Haaglanden Medical Centre
Rijnstate Hospital
Medisch Spectrum Twente
Onze Lieve Vrouwe Gasthuis
Tergooi Hospital
Amphia Hospital
Elisabeth-TweeSteden Ziekenhuis
Noordwest Ziekenhuisgroep
Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Radboud University Medical Center
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Referred for clinically indicated CFT
Exclusion criteria
* Not willing to provide informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of coronary vasomotor dysfunction | Baseline | Can be handled as dichotomous outcome with normal vs abnormal coronary function test (CFT) results. Alternatively, can also be handled as categorical outcome with the following categories. 1. Normal CFT results 2. Vasospastic endotype (epicardial or microvascular); tested by acetylcholine provocation 3. Microvascular dysfunction endotype (decreased coronary flow reserve or increased index of microvascular resistance); tested by bolus thermodilution, optionallly with additional continuous thermodilution method 4. Mixed endotype |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Angina burden | Baseline and every year up to 5 years after baseline | Measured by Seattle Angina Questionnaire summary score, 0-100 with higher scores indicating better (functional) status. |
| Experienced quality of life | Baseline and every year up to 5 years after baseline | Measured by Short Form 36, 0-100 with higher scores indicating better quality of life |
Countries
Netherlands
Outcome results
None listed