Inflammation, Post Operative Pain
Conditions
Keywords
Cryotherapy, substance P, apical periodontitis, post operative pain
Brief summary
The participants were divided into two groups: Group I (cryotherapy) (n =10) after the completion of the mechanical preparation intra oral cryotherapy was applied. Group II (control) (n =10) received standard root canal treatment without the application of any type of cryotherapy.
Detailed description
1-Patients selection: 20 patients with symptomatic apical peridontitis related to mandibular premolars were selected . After proper anestehsia, Access cavity preparation was performed. The working length measured using apex locator. chemicomechanical preparation was done. for cryotherapy group: cold pack (ice gel enveloped by a sealed plastic cover) measuring 2.5 x 5 centimetres was placed intraorally on the vestibular surface of the treated tooth for a total time of 30 minutes. apical fluid sample was collected by paper point and the root canal was then filled using gutta percha and resin-based sealer.The access cavity was sealed using glass ionomer restoration. for the control group normal treatment was done and apical fluid was collested also before obturation.
Interventions
PROCEDUREintraoral cryotherapy,ice gel
A cold pack (ice gel enveloped by a sealed plastic cover) measuring 2.5 x 5 centimetres was placed intraorally on the vestibular surface of the treated tooth. Each cold pack was kept for ten minutes.3 packs were used for each patient, for a total time of 30 minutes.Patients were instructed to remove the cold pack for 1-2 minutes if they felt extreme cold or a burning sensation .The temperature of the gel was checked by a digital thermometer (Brannan, UK) after it was removed from the freezer and kept in an ice box (Cosmoplast, UAE) containing a cooling gel (Exam Packaging, Belgium).
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Masking description
A) Sequence generation;was done using a random sequence number generated by computer software. B) Allocation Concealment Mechanism: Folded, numbered papers were placed in tightly sealed envelopes containing the patient's coding
Intervention model description
This study was designed to be a randomized, controlled, single-blinded, single-center clinical trial.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* clinical diagnosis of symptomatic apical periodontitis related to ving a mandibular single-rooted premolars * radigraphically: absence of periapical radiolucency on x ray.
Exclusion criteria
* The presence of any systemic disease or allergic reactions * Vulnerable population: prisoners, pregnant women, mentally ill people, etc. * Use of analgesic or antibiotic medication within three days * A radiographically untraceable canal
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of post operative pain using 10 cm visual analoge scale (VAS) | after 6hours, 24hours, 48hours, 72hours h, and 7days after the visit | On a10-cm Visual Analogue Scale (VAS) questionnaire, each patient reported their level of pain as follows: There is no pain at 0, 1-3, mild, 4-6, moderate, 7-9, severe, and 10, the worst pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of inflammatory mediator substance P in apical fluid | base line: immediately after procedure.the second is 30 minutes later in both groups. | Apical fluid samples were obtained using paper points size 25 passing 2 mm beyond the apex.where they were soaked by the periapical interstitial fluid for 1 minute .Four mm from the tip of each paper point was cut and dropped into 1.5-mL Eppendorf tubes (Swanscombe, UK) with 1 mL (pH 7.4) phosphate buffered saline, then stored at -80°C. Levels of substance p were measured using the ELISAtest. |
Countries
Egypt
Outcome results
None listed