Gastric Cancer
Conditions
Brief summary
Compare with the gastric cavity without cancerous transformation in atrophic gastritis, analyze the microbiota and metabolomics changes in intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.
Detailed description
This study adopts a prospective cohort study. The expected recruitment time for all participants is 6 months, and all cases are cases who would receive magnifying endoscopy examination. The extent of atrophy and the presence of early gastric cancer are determined under magnifying endoscopy. Cases are chose into the gastric cancer group and atrophic gastritis group in a 1:1 ratio. There are 16 cases of intestinal type of gastric cancer under the background of atrophic gastritis, and 16 cases of atrophic gastritis without gastric cancer matched according to gender, age, and degree of gastric atrophy, totaling 32 cases. Analyze the characteristics of early gastric cancer under endoscopy, investigate the changes in microbiota and metabolomics of intestinal type of gastric cancer under the background of atrophic gastritis, and explore the relevant mechanisms.
Interventions
None listed
Sponsors
Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* •Intestinal type of gastric cancer or atrophic gastritis * Underwent Endoscopic submucosal dissection（ESD）
Exclusion criteria
* • have simultaneously other cancer * have severe systemic inflammatory disease ,serious illness such as diabetes, chronic lung diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolomics results of lesions and atrophic gastritis. | 1year | liquid chromatograph mass spectrometer metabolic profling |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| microbiomics of lesions and atrophic gastritis. | 1 year | 16SrRNA analysis |
Other
| Measure | Time frame | Description |
|---|---|---|
| degree of gastric atrophy, | 1year | According to the classification of Kimura-Takemoto Classification （C1-O3） |
| endoscopic observation | 1year | NBI observation of atrophic background color, surrounding color of the lesion, lesion color, presence or absence of boundary transition zones, scattered intact glands within the lesion,presence of incomplete mesh patterns, and presence or absence of other early gastric cancer endoscopic manifestations. |
Countries
China
Contacts
Primary ContactHong Xu, professor
Backup ContactDong Yang, doctor
Outcome results
None listed