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The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients

The Association of Cardiac Valve Calcification and 1-year Mortality After Lower-extremity Amputation in Diabetic Patients: a Retrospective Study

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06079008
Enrollment
96
Registered
2023-10-12
Start date
2016-06-01
Completion date
2022-06-01
Last updated
2023-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amputation, Diabetic Foot, Valve Disease, Aortic, Valve Heart Disease

Brief summary

The goal of this observational study is to learn about the association between cardiac valve calcification and the 1-year mortality after lower-extremity amputation in diabetic patients. Diabetic patients requiring lower-extremity amputation were retrospectively studied. Preoperative detailed anamnesis was taken. Cardiac valve calcification was assessed using echocardiography at baseline. One-year follow-up was conducted and included clinical visits, hospital record assessment, and telephone reviews to obtain the survival status of patients. Researchers compare the survival group to the mortality group to study the relationship between the cardiac valve calcification and mortality.

Detailed description

This study aimed to investigate the association between cardiac valve calcification and 1-year mortality in diabetic patients after lower-extremity amputation. The investigator recruited consecutive patients who were admitted to the Sun Yat-sen Memorial Hospital for diabetic foot ulcers that needed amputation surgery. Clinical characteristics of each patient and the laboratory examination were collected before surgery. Cardiac valve calcification was assessed at baseline. This study obtained the survival status of patients within one year through outpatient follow-up and telephone follow-up. Researchers compared the survival group to the mortality group to see if the mortality group had a higher prevalence of heart valve calcification.

Interventions

OTHERcalcified cardiac valve

patients have cardiac cardiac valve before surgery

Sponsors

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No

Inclusion criteria

* Had echocardiography at baseline * With diabetic foot ulcers that required amputation after orthopedist's assessment

Exclusion criteria

* Fractures due to traumatic reasons that required extremity amputation * Amputation level below the ankle * Severe sepsis that required vasoactive agent treatment * Rheumatic heart disease * Heart valve surgery history

Design outcomes

Primary

MeasureTime frameDescription
The proportion of cardiac valve calcification between survival group and mortality group2017-12-1The prevalence of calcified heart valve diseases was compared between the mortality group and survival group.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026