Primary Angle Glaucoma Closure Suspect
Conditions
Brief summary
To determine whether primary angle closure suspects (PACS) in a Caucasian population benefit from prophylactic laser iridotomy.
Detailed description
Prospective, randomised paired-eye design clinical trial comparing peripheral laser iridotomy in one eye with observation in the other over 5-years follow-up.
Interventions
PROCEDUREIridotomy
Peripheral iridotomy (size \>200µm)
Sponsors
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
One eye intervention (prophylactic iridotomy), one eye no intervention
Eligibility
Sex/Gender
ALL
Age
40 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Primary angle closure suspect: ≥180 degrees (cumulative) irido-trabecular contact on darkroom gonioscopy, IOP\<21mmHg, no peripheral anterior synechiae, no glaucomatous optic neuropathy * Best-corrected visual acuity (BCVA) \>0.8 on both eyes * Caucasian
Exclusion criteria
* Pseudophakia * Previous iridotomy * Clinically significant cataract with indication for surgery, * Gaucoma * Uveitis * Unstable retinal conditions * Ocular malignancies * PEX * PDS * Systemic or ocular corticosteroid treatment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraocular pressure | 5 year | GAT: ≥24mmHg or ≥22mmHg on two separate occasions |
| Glaucoma | 5 year | The presence of glaucomatous optic neuropathy with visual field loss compatible with glaucoma. Glaucomatous optic neuropathy defined as loss of neuroretinal rim (notch or erosion), a vertical cup-to-disc ratio of more than 0.7, nerve fiber layer defect attributable to glaucoma, or both. |
| Acute Primary Angle Closure | 5 year | Presence of at least 2 of the following symptoms: ocular or periocular pain; nausea, vomiting, or both; an antecedent history of intermittent blurring of vision with haloes and IOP of more than 30 mmHg and presence of at least 3 of the following signs: conjunctival injection, corneal epithelial edema, mid-dilated unreactive pupil, glaukomflecken, and shallow anterior chamber; |
Countries
Denmark
Contacts
Primary ContactNiklas Telinius, PhD, DMSc
Outcome results
None listed