Endocytoscopy
Conditions
Keywords
tubular adenoma, IIIL duct opening, colonic innominate groove
Brief summary
This study is to analyze the characteristics of the IIIL opening of the duct in tubular adenoma and the colonic innominate groove under EC endoscopy, in order to improve the ability to tell lesions and the colonic innominate groove under EC endoscopy (Endocytoscopy).
Detailed description
This is a prospective cohort study. The recruitment time for all participants will be 4 months. The tubular adenoma group and the colonic innominate groove group will be paired in a 1:2 ratio, with 32 lesions of tubular adenoma and 64 adjacent innominate groove. It is expected that there will be 32 cases and a total of 96 observation subjects. Analyze and compare the characteristics of the opening of the IIIL duct in tubular adenomas and the colonic innominate groove under EC endoscopy, in order to summarize and differentiate them.
Interventions
PROCEDUREThe tubular adenoma group
Biopsy or removal of polyps for pathological examination. Collect baseline data such as gender, age, BMI, etc. If the pathology confirms a pure tubular adenoma, the observed object will be included in the group for final comparative analysis.
Sponsors
Jilin University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Cases of colorectal polyps discovered in our hospital and undergoing EC endoscopic examination.
Exclusion criteria
* 1.Suffering from hereditary polyposis or inflammatory bowel disease, severe intestinal inflammation, or difficulty recognizing normal intestinal mucosa; 2\. History of methylene blue allergy; 3\. Patients who have participated or are currently participating in other clinical trials within the first 4 weeks of enrollment;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of opening length to field of view | 10 minutes after the observation of Endocytoscopy | (more than 1 field of view is calculated as 1.0) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Observation of anatomical location | 10 minutes after the observation of Endocytoscopy | The anatomical site (ileocecal region, ascending colon, hepatic flexure, transverse colon, Colonic splenic region, descending colon, sigmoid colon, rectum) |
Other
| Measure | Time frame | Description |
|---|---|---|
| Morphology of IIIL type glandular opening and unnamed sulcus opening | 10 minutes after the observation of Endocytoscopy | Morphology of IIIL type glandular opening and unnamed sulcus opening after methylene blue staining.Linear or circular pit pattern. |
| Distribution characteristics of glandular opening | 10 minutes after the observation of Endocytoscopy | Magnified to the maximum magnification of EC endoscopy to the clearest cell level (approximately 520 times), and observed the morphology of the opening of the IIIL type glandular duct and the opening of the colonic innominate groove, including the morphology of cell cytoplasm and nucleus, and distribution characteristics of glandular duct openings. Regular or irregular？ |
Countries
China
Contacts
Primary ContactHong Xu, professor
Backup ContactDong Yang, doctor
Outcome results
None listed