Aging, Bariatric Surgery Candidate, Overweight and Obesity, Protein Malabsorption
Conditions
Brief summary
The goal of this clinical trial is to investigate protein digestibility after bariatric surgery. Does protein digestibility decrease after Roux-en-Y-Gastric Bypass? Does protein digestibility decrease after Sleeve Gastrectomy surgery? Does protein digestibility effect the ability to meet protein requirements?
Detailed description
Purpose of clinical trial is to investigate the digestion of dietary protein in older patients who have undergone Roux-and-Y Bypass (RYGB) or sleeve gastrectomy (SG) surgery. The primary objective is to compare dietary protein digestion during a test meal who have previously undergone a RYGB surgery, SG surgery, or control patients, using a dual stable-isotope method. The secondary objectives are to investigate the relationship between protein intake corrected for protein digestion and skeletal muscle mass, and to investigate the relationship between the rate of free amino acid appearance and protein digestion.
Interventions
OTHERDual isotope protein digestibility method
Dual isotope method
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Signed informed consent * Group 1,2,3: Age 65 years or older * Group 4,5,6: Age 18 to 65 years * Group 1,2,4,5: Previous bariatric surgery for obesity 1 - 10 years ago * Group 3,6: No previous weight loss surgery
Exclusion criteria
* Current diagnosis of cancer * Advanced organ failure, including chronic kidney disease Stage 5, liver cirrhosis Stage 3, intestinal failure, heart failure stage D, or chronic obstructive pulmonary disease stage 4. * Immobility * Neuromuscular degenerative conditions * Gastrointestinal conditions including coeliac disease, Crohn's disease, previous resection of the small intestine, gastroparesis * Unable to follow the procedures of the studies due to cognitive impairment such as diagnosed dementia. * Allergy/intolerance to milk, or soy or spirulina
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The proportion of dietary protein digested as measured by the dual-isotope method. | 3,5 hours | The proportion of dietary protein digested as measured by the dual-isotope method. |
Countries
Belgium
Outcome results
None listed