Colitis, Immune Checkpoint Inhibitor-Related Colitis
Conditions
Brief summary
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the chnages of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
Detailed description
It was previously shown that ICI-colitis can be treated with extracorporeal photophoresis. Therefore this retrospective analysis is launched to study the changes of immune cells in the peripheral blood and intestinal tract in an ICI colitis patient cohort. The analysis will include the evaluation of intestinal and peripheral blood biomarkers in patients with ICI colitis receiving ECP as a treatment.
Interventions
OTHERIntestinal tissue analysis
Intestinal tissue analysis
Sponsors
University of Freiburg
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* ICI colitis
Exclusion criteria
* no informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| T cell number and phenotype measurement in the intestinal tract | 6 months | Analysis of CD3+ T cells by flow cytometry |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| T cell number measurement by immunohistochemistry | 6 months | Analysis of CD3+ T cells by immunohistochemistry |
| Analysis of arginase amounts in the intestinal tract using qPCR | 6 months | Analysis of arginase mRNA expression by realtime PCR (qRT-PCR) |
Countries
Germany
Outcome results
None listed