Vascular Complication, Diabetic
Conditions
Keywords
Neutrophils to lymhocyte ratio and platelets to lymhocyte ratio
Brief summary
Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM
Detailed description
Vascular complications of DM result from various disorders including metabolic, cellular, and blood disturbances. Excessive production of pro-inflammatory adipokines from adipose tissue, resulting in low-grade chronic inflammation, causing insulin resistance (IR) and type 2 DM \[3\]. Hematological changes affecting the red blood cells (RBCs), white blood cells (WBCs), platelet function, and the coagulation factors are detected to be associated with DM . It is important to add that, high WBC count, one of the chief components of inflammatory process, sharing to atheroscle-rosis development and cardiovascular diseases (CVD) . Lately, the neutrophil-to-lymphocyte (N/L) and the platelet-to-lymphocyte (P/L) ratios, were offered as markers of inflammation in cardiac diseases, neoplasms and diabetes-related complications . Moreover, high leucocyte counts have been used as diagnostic and prognostic markers in vascular complication of diabetes
Interventions
RADIATIONEchocardiogram
Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* Type 2 diabetes mellitus (T2DM) patients with good glycemic control and have HBA1C \<7and ages ranging from ≥18 old. And poor glycemic control and have HBA1C ≥7 and ages rang from ≥ 18 years old
Exclusion criteria
* Patients with, type 1 diabetes mellitus 1. Idiopathic thrombocytopenic purpura, 2. liver cell failure 3. Myeloproliferative neoplasm 4. patients on anticoagulant drugs , anti platelet drugs or on steroids were excluded from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neutrophil-to-lymphocyte ratio and platelets to lymphocytes ratio | Basline | Measurement of Neutrophils to lymhocyte ratio and platelets to lymhocyte ratio in patients with type 2 DM |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| HbA1c with good glycemic control and have HBA1C lower than 7and poor glycemic control and have HBA1C higher than 7with prescence or abscence of vascular complications | Basline | Evaluate PLR and NLR and their assiotation to vascular complications and glycemic control in type 2 DM |
Contacts
Primary ContactAmmar Ashraf Fathy
Backup ContactSalah abdelazem Argoon
Outcome results
None listed