Oxygen Consumption
Conditions
Keywords
intensive care, jugular vein catheter, radial artery catheter
Brief summary
The goal of this observational study is to find out if researchers can measure oxygen consumption in the body without having to draw blood from lines in arteries and central veins. Participants will undergo measurements of arterial blood oxygen saturation using both finger and neck pulse oximeters.
Detailed description
TOUCAN-1 is a study to estimate the accuracy and precision of pulse oximetry as a noninvasive tool for oxygen consumption measurement. Researchers will use a pair of commercially-available, noninvasive pulse oximeters to estimate the oxygen saturation of blood in the internal jugular vein, and compare it to the directly measured oxygen saturation in sampled jugular blood. Researchers will then measure the arterial oxygen saturation in a finger, and compare it to the directly measured oxygen saturation in sampled radial arterial blood.
Interventions
DEVICEFinger pulse oximetry probe
This finger probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.
DEVICETransreflectance oximetry probe
This neck probe will be used to make noninvasive measurements of systemic arterial and central venous oxygen saturations.
Sponsors
AABB Foundation
University of Wisconsin, Madison
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Inpatient at the University of Wisconsin University Hospital * Has an internal jugular venous central line * Has a radial arterial line
Exclusion criteria
* Currently receiving extracorporeal membrane oxygenation (ECMO) * Currently receiving continuous renal replacement therapy (CRRT/CVVH) * All usable lumens of the participant's jugular catheter are in use, and interruption of any medical or therapy through any lumen would, in the view of the primary care team, compromise the participant's care. * Jugular venous catheter is not functional or position is not confirmed by radiography * Arterial cannula is not functional * Known history of sickle cell anemia or other hemoglobinopathy * Therapy with any of the following medications: * Nitroprusside * Hydroxocobalamin * Indocyanine green * Norepinephrine * Vasopressin * Epinephrine * Any other medication or therapy that, in the judgement of the study investigators, may affect the accuracy and precision of the noninvasive oximetry results
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Accuracy of digital pulse oximetry | Through study completion, approximately 20 minutes | Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry |
| Accuracy of jugular pulse oximetry | Through study completion, approximately 20 minutes | Difference in the standard deviation of the arteriovenous saturation difference comparing noninvasive photoplethysmography to invasive blood sampling and oximetry |
Countries
United States
Outcome results
None listed