Growth Retardation
Conditions
Brief summary
This study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.
Detailed description
At present, it is unclear when to cease parenteral nutrition, the effects of cessation times on preterm infants' growth, and whether insulin-like growth factor 1 (IGF-1) has a mediation effect in the procedure that nutrients regulate the growth in preterm infants. Therefore, a prospective cohort study was designed with the aims: 1. to estimate the association between the time to cease parenteral nutrition and the growth in very low birth weight; 2. to investigate the relationship between nutrient volume in parenteral nutrition and growth in very low birth weight; 3. to analyze the IGF-1 mediation effect between nutrient volume and growth regulations.
Interventions
OTHER(enteral feeding volume/ total fluid volume)*100%
(enteral feeding volume/ total fluid volume)\*100%. Total fluid volume is defined as enteral feeding volume + parenteral fluid volume + other fluid volume
Sponsors
Peking University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
1. Infants with a birth weight less than 1500 grams 2. Infants admitted within 72 hours after birth 3. Infants born from July 1, 2023, to June 30, 2024 4. Written informed consent from parents or guardians
Exclusion criteria
1. Infants with congenital abnormality 2. Infants surviving \<7 days after birth
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| short-term weight and long-term weight | at 36 weeks' corrected age (CA), CA 3 months, CA 6 months, CA 12 months, CA 18 months, CA 24 months, 36 months' age, 48 months' age and 60 months' age | weight |
| short-term head circumference and long-term head circumference | at 36 weeks' corrected age (CA), CA 3 months, CA 6 months, CA 12 months, CA 18 months, CA 24 months, 36 months' age, 48 months' age and 60 months' age | head circumference |
| short-term length and long-term length | at 36 weeks' corrected age (CA), CA 3 months, CA 6 months, CA 12 months, CA 18 months, CA 24 months, 36 months' age, 48 months' age and 60 months' age | length |
Countries
China
Contacts
Primary ContactShuaijun Li, doctor
Backup ContactShuag Zhou, doctor
Outcome results
None listed