Nailfold Capillaroscopic Assessment in Pediatric Uveitis Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06070935

Enrollment

Registered

2023-10-06

Start date

2024-01-01

Completion date

2024-06-30

Last updated

2024-08-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uveitis

Brief summary

Pediatric uveitis accounts for 5-10% of uveitis cases. it may be infectious or noninfectious in etiology. The etiology of noninfectious uveitis may be autoimmune. The most common causes of pediatric uveitis are idiopathic and juvenile idiopathic arthritis-associated uveitis. Uveitis morbidities in pediatric patients include cataract, glaucoma, and amblyopia. Pediatric uveitis may be accopanied by involvement of the ocular vasculature, such as retinal vasculitis. We hypothesize that there are differences in systemic microcirculation between pediatric uveitis patients and healthy pediatric controls.

Detailed description

The systemic microcirculation will be investigated through nailfold capillaroscopic (NFC) assessment with noninfectious uveitis and healthy pediatric controls. The NFC parameters are: capillary density (number of capillaries per mm), dilated capillaries (apex of \>20µm), avascular areas, the presence of microhemorrhages, and capillary morphology (normal, multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries).

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

No minimum to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* patients with uveitis \< 18 years old

Exclusion criteria

* infectious uveitis * age \> 18 years old

Design outcomes

Primary

Measure	Time frame	Description
capillary density by nailfold capillaroscopy	6 months	(number of capillaries per mm)
detection of number of dilated capillaries by nailfold capillaroscopy	6 months	number of dilated capillaries (apex of \>20µm)
detection of other abnormalities as avascular areas, microhemorrhages, and abnormal capillary morphology	6 months	detection of multiple crossings, tortuous, bushy, ramified, non-convex, or bizarre capillaries

Secondary

Measure	Time frame	Description
correlation of nailfold findings with uveitis activity	6 months	correlation of capillary abnormalities detected with active uveitis.

Countries

Egypt

Outcome results