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Effects of Different Types of Anaesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery

Effects of Propofol, Desflurane and Spinal Anesthesia on Intraocular Pressure During Lumbar Disc Herniation Surgery: A Randomized Controlled Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06070480
Enrollment
75
Registered
2023-10-06
Start date
2022-01-05
Completion date
2023-05-15
Last updated
2023-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Disk Herniated Lumbar, Intraocular Pressure

Keywords

prone position, intraocular pressure, hemodynamics, anesthesia,spinal, anesthesia,general

Brief summary

The aim of this study was to investigate the effects of anaesthesia methods on intraocular pressure during lumbar disc surgery performed in the prone position.

Detailed description

The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure (IOP) was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Interventions

Effect of spinal anesthesia on intraocular pressure

Effect of general anesthesia with desflurane on intraocular pressure

OTHERPropofol Group

Effect of general anesthesia with propofol on intraocular pressure

Sponsors

Giresun University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE

Intervention model description

The study included 75 patients with lumbar disc herniation between the ages of 18-75, with the American Society of Anesthesiologists (ASA) 1-2. The patients were randomly divided into 3 groups: propofol, desflurane, spinal. Intraocular pressure was measured at 5 time points throughout surgery, including baseline (T1), 10 minutes after anesthesia (T2), 10 minutes after prone positioning (T3: early prone), 30 minutes after prone positioning (T4: late prone), and 10 minutes after returning to the supine position (T5). Hemodynamic parameters were measured at these time points. Hemoglobin and hematocrit values were measured preoperatively and on the first postoperative day.

Eligibility

Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* ASA 1-2 according to the American Society of Anesthesiologists (ASA) Classification.

Exclusion criteria

* Who did not sign the informed consent form, * patients who required emergency surgery, * eye surgery recipients, * subjects with acute or chronic eye diseases other than refractive errors, * individuals detected to have elevated IOP in preoperative measurements

Design outcomes

Primary

MeasureTime frameDescription
intraocular pressureTime 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supineIntraocular pressure was measured a total of 5 times at set time points throughout the procedures.

Secondary

MeasureTime frameDescription
Mean Arterial PressureTime 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supineMean Arterial Pressure was measured a total of 5 times at set time points throughout the procedures.
Heart RateTime 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supineHeart Rate was measured a total of 5 times at set time points throughout the procedures.
End Tidal Carbon Dioxide (CO2)Time 1:baseline supine , Time 2: 10. minute supine, Time 3: 20. minute prone , Time 4: 30. minute prone,Time 5: 10. minute after returning to the supineEnd Tidal CO2 was measured a total of 5 times at set time points throughout the procedures.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026