Acute Respiratory Distress Syndrome
Conditions
Keywords
ARDS; mortality; incidence; prognosis; predictive model; AI
Brief summary
This project intends to adopt the multicenter prospective real-world study method to conduct a preliminary study on the incidence, grading, risk factors, respiratory support strategies, in-hospital mortality, 3-month mortality, 6-month mortality, 1-year mortality, quality of life, lung function and limb function recovery, cognitive function, return to work and other conditions of ARDS patients in RICU. By collecting 1,000 patients, a clinical database related to ARDS in China was established to provide essential data and ideas for promoting standardized diagnosis and treatment technology for ARDS patients and further clinical intervention research. At the same time, ARDS biobank was established in China-Japan Hospital and Xiangya Hospital to realize the integration of clinical data and sample resources, and the prediction model of ARDS survival and complications of tuberculosis clinical data and biological samples was established by using big data and AI technology.
Interventions
None listed
Sponsors
China-Japan Friendship Hospital
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* New or worsening respiratory symptoms less than 7 days after the acute blow. * CT/X-ray: Double lung infiltration that cannot be fully explained by pleural effusion, lobar/whole atelectasis, and nodule. * Respiratory failure that cannot be explained by heart failure or fluid overload * After 15min assisted ventilation (PEEP or CPAP ≥ 5cmH2O) or HFNC with flow≥30L/min, PaO2/FiO2≤300mmHg * Classification of ARDS: mild (200mmHg \< PaO2/FIO2 ≤ 300mmHg), moderate (100mmHg \< PaO2/FIO2 ≤ 200mmHg), and severe (PaO2/FIO2 ≤ 100mmHg) and 4 ancillary variables for severe ARDS
Exclusion criteria
* younger than 18 years old * Patients or family members refused to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the prognosis of ARDS patients | from 28d to 1 year | ICU mortality, 28-day mortality, 90-day mortality and 1-year mortality of ARDS patients |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of hospital stay in ARDS patients | during hospitalization | Length of hospital stay in ARDS patients |
| VFDs within 28 days | 28 days | Mechanical ventilation free days within 28 days |
| Long-term quality of life and long-term lung function | 1 year | 3month，6month，1year quality of life score and 1year lung function |
| Incidence of ARDS in ICUs | 2 years | Incidence of ARDS in ICUs |
| Survival risk factors in hospitalized ARDS patients | during hospitalization | Survival risk factors in hospitalized ARDS patients |
| Risk factors for ARDS complications | during hospitalization | Risk factors for ARDS complications（including AKI and barotrauma） |
| Rates of mechanical ventilation strategies are consistent with guidelines rates of rates of mechanical ventilation strategies consistent with guidelines | during hospitalization | consistence of lung protective ventilation strategies（including small tidal volume and limitation of Pplat） |
Countries
China
Outcome results
None listed