Aging
Conditions
Keywords
sedentary behavior, physical activity, cognitive function, vascular function
Brief summary
The aim of this project will be to compare the acute effects of breaks from sedentary behavior using dual-tasking on cerebral blood flow, vascular function, cognitive functions and blood pressure in elderly people. Participants will perform, in random order, three experimental sessions (control, break with dual-task and standard break (\[walk\]). All sessions will have a period of 4 hours in sedentary behavior. In the standard break session and in the break session with dual-task participants will take walking and dual-task breaks every 30 minutes, and in the control session they will remain seated without breaks. Before and after this period, cerebral blood flow, vascular function, cognitive functions and blood pressure will be assessed.
Interventions
OTHERBreak of sedentary behavior with dual task
Patients will interrupt sedentary behavior performing walking and cognitive activities simultaneously
OTHERBreak of sedentary behavior with walking
Patients will interrupt sedentary behavior performing walking
Sponsors
University of Nove de Julho
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Masking description
The evaluator of flow-mediated dilation is blinded
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* aged 60 years or over * be physically independent based on the Katz Test * have no history of heart attack * not having suffered a stroke * not have heart failure * do not have joint problems that prevent them from carrying out experimental sessions * do not have a history of neurodegenerative diseases * obtain ≥ 26 points in the Montreal Cognitive Assessment (MoCA) * are not involved in the practice of regular, systematic physical activity more than once a week over the last six months prior to the start of the study * not be smokers and morbidly obese.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function - verbal fluency [number of animal names reported] | Before and 35 minutes after the intervention | The task will consist of recalling words that begin with the letter F, for 60 seconds. The final score will be determined according to the number of correct words reported in 60 seconds. In the semantic modality, participants must evoke as many animals as possible in 60 seconds. The final score will be determined according to the number of animal names reported in 60 seconds. |
| Cerebral blood velocity [centimeters per second] | Before and 20 minutes after the intervention for 5 minutes | Mean arterial velocity of middle cerebral artery will be measured using a transcranial doppler |
| Cognitive function - The Trail Making Tests [seconds] | Before and 30 minutes after the intervention | The Trail Making Tests (A and B) will be used to assess executive function and attention. Part A will determine psychomotor speed and require the participant to draw lines connecting sequentially circled numbers, such as drawing a line from 1 to 2, 2 to 3, and 3 to 4. Part B will consist of circled numbers and letters. Participants will be instructed to draw a line as quickly and as accurately as possible from 1 to A, A to 2, 2 to B, B to 3, and so on, until they complete the task. The time in seconds will be recorded in seconds after the end of each stage. After carrying out the tests, the differences between the completion times for part B - A will be calculated. |
| Cognitive function - Stroop test [seconds] | Before and 32 minutes after the intervention | A computerized version of the Stroop test will be used in this study, using the Testinpacs® program. The tasks will be viewed on a notebook screen approximately 90 cm away from the participant. Answers to a set of tasks will be given as quickly as possible via two buttons. The cognitive portion of the Stroop test will be used as a psychometric test to assess cognition, being related to the executive functions of decision-making and inhibitory control exercised by the prefrontal cortex. The capacity for selective attention and response control will be estimated as the time difference between the third condition and the second condition. Smaller differences will indicate better selective attention and conflict resolution. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting systolic and diastolic blood pressures [mmHg] | Before and 10 minutes after the intervention | Resting systolic and diastolic blood pressures will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan). |
| Resting heart rate [bpm] | Before and 10 minutes after the intervention | Resting heart rate will be assessed with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan). |
| Ambulatory systolic, diastolic, and mean blood pressures monitoring [mmHg] | 45 minutes after the intervention | The systolic, diastolic, and mean blood pressures during 24 hours will be measured using a non-invasive oscillometric device (Dynamapa) |
| Vascular function [%] | Before and 10 minutes after the intervention | Vascular function will be measured with the flow-mediated dilation according to the global recommendations on popliteal artery before and after 15 minutes of intervention by a bidimensional ultrasonography device with spectral Doppler and linear transducer. |
Countries
Brazil
Outcome results
None listed