CCT, Chaperonin-Containing TCP-1, Circulating Tumor Cells, CTC
Conditions
Keywords
Healthy
Brief summary
The purpose of this study is to develop a liquid biopsy approach for detection of circulating tumor cells (CTC) that could be used in place of the more invasive and potentially risky methods of tissue biopsy. The aims of the project are: (a) determine whether the Chaperonin-Containing TCP-1 (CCT) chaperonin can used to identify rare cancer cells in blood, and (b) establish whether the cancer cells detected using the CCT chaperonin for identification have invasive or metastatic potential.
Interventions
None listed
Sponsors
University of Central Florida
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female * Age greater than or equal to 18 and less than or equal to 80 years.
Exclusion criteria
* Adults unable to give informed consent * Individuals who are not yet adults (infants, children, teenagers; under the age of 18) * Individuals who weigh less than 110 lbs (as standard clinically advised to not give blood) * Pregnant women (due to hormonal changes in blood) * Prisoners * Persons reporting a current microbial (bacterial, viral, or fungal) infections * Persons reporting that they are current taking antibiotic medications * Persons with body temperatures above 99oF (indicating a fever)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if the biomarker, Chaperonin-Containing TCP-1 (CCT), can be used to detect circulating tumor cells (CTC) in blood. | 3 years |
Secondary
| Measure | Time frame |
|---|---|
| To determine if the CCT chaperonin can provide information on the metastatic potential of CTC. | 3 years |
Countries
United States
Outcome results
None listed