Asthma
Conditions
Keywords
allergy, Immunity, Healthy, respiratory, ENT
Brief summary
The purpose of this study is to determine whether a potential type 2 signature, obtained through stimulation of cell lines with various allergens in vitro, correlates with an allergic or asthmatic disease state ex vivo. This type 2 signature will be multi-hierarchical in nature and will be comprised cell surface receptor expression, pathway activation, and gene upregulation.
Interventions
None listed
Sponsors
University of Central Florida
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Participants must be at least 18 years of age * no history of allergic disease (healthy controls), have clinically diagnosed allergies, or have clinically diagnosed asthma.
Exclusion criteria
* Pregnant women and prisoners will be excluded from the study. * Individuals currently suffering from any acute infections and those known to suffer from light-headedness will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine which parameters of the established type-2 signature obtained in vitro is significantly different between healthy controls, allergic individuals, and asthmatic individuals ex vivo. | 1 year |
Secondary
| Measure | Time frame |
|---|---|
| To determine ex vivo whether any of the identified disease-specific type-2 parameters can be modified (brought back to healthy control levels) through the use of investigational compounds. | 1 year |
Countries
United States
Contacts
Primary ContactAmoy Fraser, PhD, CCRP, PMP
Backup ContactErica Martin, B.S.
Outcome results
None listed