Spinal Cord Injuries, Spinal Cord Diseases
Conditions
Brief summary
Patients arriving to rehabilitation up to 3 months following SCI will be given (study group) or not (control group) Lyrica (75X2). They will be followed for central pain development.
Detailed description
Patients arriving to rehabilitation up to 3 months following SCI will be recruited, if they have not yet developed central pain. Two thirds (the study group) will be treated with Lyrica (Pregabalin75X2) for 3 months. One third (the control group) will not receive preventative treatment. Participants will be followed for central pain development.
Interventions
DRUGPregabalin 75mg
Pregabalin 75 mg twice a day
Sponsors
Loewenstein Hospital
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
allocation will be sequential. 2 patients will be in the study group, followed by one patient at the control group.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Up to 3 months following traumatic or non-traumatic SCL * Ability to give informed consent and cooperate
Exclusion criteria
* Pregnancy * Neurological or other medical conditions that may interfere with sensation * Neuropathic-like pain before recruitment (described as painful sensation of electric current, burning, numbness, tingling, pricking, or squeezing) * Being treated with Pregabalin * Blood creatinine levels \>1.2 or creatinine clearance \<60 * Sensitivity to lactose
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Central pain | 1 year | development of central pain by interview (yes /no ) |
| McGill Pain Questionnaire | 3 months | Range 0 -78. higher scores mean worse outcome. |
Countries
Israel
Contacts
Primary ContactAmiram Catz, Prof.
Outcome results
None listed