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Effect of Non-nutritive Sucking on Feeding Intolerance

Effect of Non-nutritive Sucking on Feeding Intolerance in Premature Infants

Status
Recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06065839
Enrollment
180
Registered
2023-10-04
Start date
2022-09-20
Completion date
2024-08-16
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-nutritive Sucking

Brief summary

The design of this study is an experimental research design, and the research subjects who meet the conditions of acceptance will be used as randomized controlled trials. Cases meeting the sampling conditions in the neonatal intensive care unit were stratified according to birth weeks (26 to 27+6 weeks and 28 to 31+6 weeks), and then randomly assigned to experimental group A (non-nutritive sucking 5 minutes), experimental group B (non-nutritive sucking for 15 minutes) and control group (no non-nutritive sucking). The variables controlled in this study were gestational weeks, birth weight, sex, Apgar score, respirator use, and type of milk fed. The premature infants in the experimental group were given non-nutritive sucking before the first tube-feeding and the feeding volume reached 10mL/kg/day, while the control group was not given non-nutritive sucking before tube-feeding. The interventional measures adopted in this study were set as two meals a day before 17:00, and the patients were force-fed every three hours, and the time interval between the two interventional measures was every six hours (intervention measures were provided every other meal) , the measurement time, times and intervals of the two groups are the same. Experimental group A was given pacifier NNS 5 minutes before each feeding, experimental group B was given pacifier NNS 15 minutes before each feeding, while the control group was not given NNS before feeding, and the two groups were given 150 minutes after feeding (ie 30 minutes before the next force-feeding) to monitor gastric residual volume, changes in abdominal circumference, and vomiting. Since FI mainly occurred 48-72 hours after the start of feeding, the duration of this study was 3 consecutive days to compare with the control group. The acceptance conditions of the research objects are: 1. Premature infants whose gestational age is more than 26 weeks (inclusive) to less than 32 weeks, 2. Premature neonates who have been placed with orogastric tube or nasogastric tube for force-feeding, 3. No congenital gastrointestinal tract Abnormal, 4. No serious congenital abnormalities and heart disease, no cleft lip and palate, 5. Never received stomach or intestinal surgery, 6. No central nervous system damage, 7. With the consent of their parents or guardians, and fill out the consent form By. If the condition is unstable during the course of the case, including severe hypoxemia, hypotension, esophageal perforation, necrotic enteritis, sepsis caused by infection, and grade 3-4 intraventricular hemorrhage, etc., they will be excluded.

Interventions

OTHERnon-nutritive sucking 5 minutes

Give pacifier non-nutritive sucking for 5 minutes before feeding

OTHERnon-nutritive sucking 15 minutes

Give pacifier non-nutritive sucking for 15 minutes before feeding

Sponsors

Chang Gung Memorial Hospital
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
26 Weeks to 32 Weeks
Healthy volunteers
Yes

Inclusion criteria

* Premature infants whose gestational age is more than 26 weeks (inclusive) to less than 32 weeks * Premature neonates who are force-fed with orogastric or nasogastric tubes * No congenital gastrointestinal abnormalities * No serious Congenital anomalies and heart disease, no cleft lip and palate * Never received stomach or intestinal surgery * No central nervous system damage * With the consent of their parents or guardians, and fill out the consent form.

Exclusion criteria

* Severe hypoxemia * Severe hypotension * Esophageal perforation * Necrotic enteritis * Infection-induced sepsis * 3-4 grades of ventricular hemorrhage

Design outcomes

Primary

MeasureTime frameDescription
feeding intoleranceThe test was carried out twice a day, with an interval of 6 hours between each data collection, and the test was carried out continuously for 3 daysGastric residual volume in milliliter

Countries

Taiwan

Contacts

Primary ContactYu-Ting HUANG, BSN
Bunny@cgmh.org.tw+886975832680
Backup ContactYu-Ting HUANG, BSN
+88633281200

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026