Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department

Potential Diagnostic Biomarkers for Aortic Dissection in the Emergency Department: the Aggrecan, Desmosine, D-dimer-Emergency Department (ADD-ED) Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06065306

Acronym

ADD-ED

Enrollment

Registered

2023-10-03

Start date

2023-06-18

Completion date

2025-12-31

Last updated

2024-04-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic Dissection

Keywords

aortic dissection, biomarker, diagnostic, d-dimer, aggrecan, desmosine

Brief summary

The goal of this observational study is to determine the utility of desmosine, D-dimer and aggrecan as early diagnostic biomarkers in aortic dissection. The main questions it aims to answer are: * To investigate the plasma levels of selected biomarkers in ED patients with confirmed aortic dissection * To study the diagnostic performance of plasma levels of selected biomarkers for aortic dissection * To study the association between plasma levels of selected biomarkers and clinical outcomes

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Age ≥ 18 years * Presentation to the ED with first 24 hours of symptoms suggesting AD, including chest pain, upper back pain, syncope of unknown cause, symptoms of any acute perfusion deficit * Confirmed AD * the diagnosis of AD adjudicated by an independent expert panel at hospital discharge or death, whichever comes first * The expert panel will consist of (1) a specialist in Emergency Medicine and (2) a specialist in Cardiology and (3) a specialist in Cardiothoracic Surgery.

Exclusion criteria

* Age \<18 years old * Pregnancy * Surgery or stenting performed before recruitment

Design outcomes

Primary

Measure	Time frame	Description
Serum levels of D-Dimer, Aggrecan and Desmosine	Blood samples taken preoperatively	Biomarkers :Serum levels of D-Dimer, Aggrecan and Desmosine will be compared in patients with confirmed AD versus age and sex matched healthy controls

Countries

Hong Kong

Contacts

Primary ContactColin A Graham

cagraham@cuhk.edu.hk+85235051033

Backup ContactTheresa Hui

theresahui@cuhk.edu.hk+85235051698

Outcome results