Cardiorenal Syndrome Type 1
Conditions
Brief summary
A double-blind, randomized, controlled trial was conducted with the main objective of evaluating if patients with clinical assessment and VExUS reach decongestion faster within a maximum period of 7 days during the hospital stay. Likewise, the study will describe those patients who experience a decrease in serum creatinine (CrS), NT-proBNP at discharge, greater diuretic adjustment, rate of intrahospital readmission, and 30-day mortality.
Interventions
OTHERDiuretic de/escalation based on ultrasound findings (VExUS Score)
Patients allocated in the experimental arm will have diuretic dosing adjusted based on ultrasound findings (VExUS Score)
OTHERDiuretic de/escalation based on clinical findings (CCS Score)
Patients allocated in the experimental arm will have diuretic dosing adjusted based on clinical findings (CCS Score)
Sponsors
EchoNous Inc.
Instituto Nacional de Cardiologia Ignacio Chavez
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Intervention model description
Experimental, randomized, double-blind, and prospective study
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* 18 years old or older * Type 1 cardiorenal syndrome in emergency room at Instituto Nacional de Cardiologia Ignacio Chávez
Exclusion criteria
* Patients who denied to participate * Liver disease (cirrohsis) * Complex congenital heart disease * Kidney transplant * Heart transplant * Severe valvular disease * Chronic kidney disease KDIGO G5 and G5d * INTERMACS Score 2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Decongestion within 7 days | 7 days | Assess if the ultrasound guided arm achieves faster decongestion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants that initiate kidney replacement therapy | 30 days | Assess which strategy is associated with kidney replacement therapy |
| Intrahospital mortality | 30 days | Assess which strategy achieves less intrahospital mortality |
| Total diuretic dose within 7 days | 7 days | Assess which strategy has greater diuretic adjustment |
| Acutely decompensated heart failure readmission rate | 7 days | Assess which strategy achieves less readmission rate |
| Length of hospital stay | 7 days | Assess which strategy achieves fewer days of hospital stay |
| Days alive out of hospital | 1 month | Assess which strategy achieves more days alive out of hospital |
Countries
Mexico
Contacts
Primary ContactSalvador López Gil, MD
Backup ContactVictor H Gomez Johnson, MD
Outcome results
None listed