Periodontitis, Adult
Conditions
Brief summary
Aim: The aim of the current study was to compare and correlate gingival crevicular fluid (GCF) fetuin-A levels and high sensitivity C-reactive protein (hs-CRP) levels in non-diabetic periodontitis patients and type 2 diabetic periodontitis patients with healthy subjects and revealing its possible role in diagnosis of periodontal disease. Methodology: Forty-five periodontitis stage III patients categorized into 3 groups according to whether having type II diabetes mellitus or not were compared to systemically and periodontally healthy participants in this investigation. Clinical parameters for all groups were recorded. Assessment of GCF levels of fetuin A and hs-CRP were done to all enrolled participants utilizing an enzyme linked immune-sorbent assay (ELISA) kit. Receiver operating characteristic (ROC) curve was performed to reveal sensitivity, specificity, predictive value and diagnostic accuracy of the markers used.
Interventions
DIAGNOSTIC_TESTGCF levels of fetuin A and hsCRP evaluation
ELIZA kits are used for GCF levels of fetuin A and hsCRP evaluation
Sponsors
Fayoum University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* both gender periodontitis stage III
Exclusion criteria
1. Smoking, 2. Systemic diseases (except DM in group B), 3. Periodontitis patients having periodontal treatment recently (past 6 months), 4. Pregnancy, lactation, contraceptive pills, 5. Anti-inflammatory/ immunosuppressive drugs.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| GCF levels of fetuin A and hsCRP evaluation in all groups | levels of fetuin A and hsCRP are measured at baseline after the completion of all GCF sample collection carried at the day of enrollment of subjects in the investigation after diagnosis confirmation | ELIZA kits |
Countries
Egypt
Outcome results
None listed