Bedside Tests of Cardiorespiratory Fitness

Exploring the Utility of Bedside Tests for Predicting Cardiorespiratory Fitness in Older Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06062784

Enrollment

Registered

2023-10-02

Start date

2019-01-01

Completion date

2021-12-31

Last updated

2025-09-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aging

Brief summary

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics and bedside measures of physical function and muscle size to predict cardiorespiratory fitness.

Detailed description

A study of 64 older adults over the age of 65y to assess the utility of patient characteristics (age, gender and BMI) and bedside measures of physical function (handgrip strength (HGS) and step box test) and muscle size (muscle thickness via B-mode ultrasonography (US)) to predict cardiorespiratory fitness (VO2peak and anaerobic threshold) as measured by the gold-standard assessment method, cardiopulmonary exercise testing (CPET). Each participant will take part in a single assessment day (after health screening against CPET safety criteria) whereby they will have US measures of the vastus lateralis before completing HGS and step box test assessments, and finally a CPET.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

OTHER

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Over 65y * Independent, community-dwelling

Exclusion criteria

* Contraindications to CPET safety criteria

Design outcomes

Primary

Measure	Time frame	Description
Cardiorespiratory fitness (CRF) - VO2 max	Single time-point - 8 to 12 minutes	CRF via cardiopulmonary exercise testing (CPET). This includes a measure of maximum oxygen uptake (VO2 max) determined via inline breath gas analysis during an incremental cycle test.
Cardiorespiratory fitness (CRF) - Anaerobic threshold	Single time-point - 8 to 12 minutes	CRF via cardiopulmonary exercise testing (CPET). This includes a measure of anaerobic threshold (AT) determined via inline breath gas analysis during an incremental cycle test.

Secondary

Measure	Time frame	Description
Muscle architecture - muscle thickness	Single time-point: 10 minutes	Analysis of vastus lateralis muscle thickness using b-mode ultrasonography
Muscle architecture - pennation angle	Single time-point: 10 minutes	Analysis of vastus lateralis pennation angle using b-mode ultrasonography
Muscle architecture - fascicle length	Single time-point: 10 minutes	Analysis of vastus lateralis fascicle length using b-mode ultrasonography

Countries

United Kingdom

Outcome results