Hunger
Conditions
Keywords
Satiety, Appetite
Brief summary
This project will assess the effect of Huel powdered food on the satiety of 40 generally healthy volunteers compared to a standard breakfast of cornflakes and milk. To achieve this, we will recruit 40 (non-smoking) generally healthy volunteers to attend the study centre on two separate occasions. On each occasion they will arrive at the study centre fasted and will be given their breakfast of either Huel or Cornflakes and milk, matched for calorie content. The aim is to identify the size and duration of any effect on satiety of the two meals.
Detailed description
This project will assess the effect of Huel Food replacement on the satiety of 40 generally healthy volunteers compared to a standard breakfast of cornflakes and milk. To achieve this, we will recruit 40 (non-smoking) generally healthy volunteers to attend the study centre on two separate occasions. On each occasion they will arrive at the study centre fasted and will be given their breakfast of either Huel or Cornflakes and milk, matched for calorie content. We will ask volunteers to come to the research facility in Newcastle University, before they have had any breakfast, on two separate occasions. The volunteers must not eat or drink anything (except water) after 8 pm the evening before they come in. This includes not drinking any alcohol, tea, or coffee. BMI, weight, and body composition (measured via electrical impedance) will also be taken at the initial visit to ensure they meet the inclusion criteria All volunteers will be asked to complete screening questionnaires focusing on morning eating and exercise routine and the 'three factor eating' questionnaire before or during their screening visit. A subset of volunteers (eight in total) will be recruited to collected blood samples throughout the two study visits. These volunteers will go through the same screening process but will also have their veins assessed for cannulation suitability. During the two study visits, both sets of volunteers will be asked to complete appetite questionnaires every 15 minutes for the first hour and every 30 minutes for the remaining 3 hours. Volunteers who have consented to provide blood samples will be asked to give samples just before they complete the appetite questionnaires. The blood samples will be assessed for Ghrelin, CCK, PYY, Glucose, and Insulin. All researchers are trained in GCP, phlebotomy and cannulation.
Interventions
OTHERHuel Powder
Huel Powder v3.0 white, vanilla flavour
Sponsors
Newcastle University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Randomised, open label crossover study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Generally Healthy * Non-pregnant/lactating * No known food allergies * BMI between 20-30
Exclusion criteria
* Diagnosed eating disorder * receiving regular medication (except contraceptives or statins) * long-term illness such as high blood pressure, heart disease * taking medication that can affect kidney function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hunger Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | How hungry do you feel? |
| Satisfied Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | How satisfied do you feel? |
| Fullness Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | How full do you feel? |
| How much can you eat Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | How much do you think you can eat? |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PYY | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Concentration of Peptide YY in plasma (pg/ml) |
| Ghrelin | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Concentration of Ghrelin in plasma (pg/ml) |
| Sweet Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Would you like to eat something sweet? |
| Glucose | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Concentration of glucose in plasma (mmol/l) |
| Insulin | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Concentration of Insulin in plasma (pmol/l) |
| CCK | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Concentration of Cholecystokinin in plasma (pg/ml) |
| Salty Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Would you like to eat something salty? |
| Savoury Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Would you like to eat something savoury? |
| Fatty Visual Analogue Score | 0, 15, 30, 45, 60, 90, 120, 150, 180, 210, 240 minutes | Would you like to eat something fatty? |
Outcome results
None listed