Body Composition, Lean Body Mass, Muscle Power, Muscle Strength
Conditions
Brief summary
The effect of resistance training with post-exercise Collagen peptides (CP) supplementation on lean body mass, maximal and explosive, isometric muscle strength as well as fat mass, resting metabolism, health parameters and compared to resistance training alone will be evaluated in a group of untrained overweight male (30-60 yrs) population in a randomized controlled trial (RCT).
Detailed description
Participants will perform supervised resistance training involving (Leg press, pull down, chest press, back extension and abdominal crunches) 3 times a week for 12 weeks. Participants will consume either placebo or collagen peptides (in a double blinded study design) just following resistance training on training days (And approximately the same time of day on non-training days). Prior to, and following 12 weeks of exercise, participants will be tested in body composition, maximal and explosive, isometric muscle strength, resting metabolism, health parameters. Additionally, blood samples will be taken to ensure health and training eligibility and safety. Participants are healthy untrained overweight males (30-60 yrs)
Interventions
DIETARY_SUPPLEMENTEffect of collagen peptides, in combination with resistance training, on body composition and muscle strength compared to placebo in untrained men
The effects of collagen peptide consumption in combination with resistance training will be tested
DIETARY_SUPPLEMENTPlacebo Control intervention: Effect of resistance training in combination with placebo (silicon dioxide), on body composition and muscle strength in untrained men
The effects of placebo consumption in combination with resistance training will be tested
Sponsors
University of Southern Denmark
CRI Collagen Research Institute GmbH
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Masking description
Participants will be allocated to either placebo or collagen peptide supplementation in a double blinded randomized design. Only following completion of all participants will the blinding be removed
Intervention model description
A double blinded randomized controlled trial
Eligibility
Sex/Gender
MALE
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Male, between 30 and 60 years of age * Fat mass \>25 % as measured by bioelectrical impedance analysis * Stable weight (±5 %) and eating behaviour within the last 3 months. * Signed informed consent
Exclusion criteria
* Regular physical activity \>60 min / week * Stabile or progressive diseases/conditions (including medication) contraindicating or disabling participation in intensive exercise training and/or with potential to affect training adaptation beyond normal variation. For example: * Contraindications against physical stress corresponding guidelines of American College of Sports Medicine (ACSM) * Subjective symptoms during exercise (e.g., unusual physical exhaustion, dyspnoea, nausea) * Moderate to severe mobility limitation (i.e., due to rheumatic disease) * Diagnosis of cancer within the last 5 years * Diabetes mellitus I and II uncontrolled arterial hypertension (systolic blood pressure \>155 for mmHg and/or diastolic blood pressure \>94 mm Hg; mild hypertension under resting condition will be allowed but such participants will be recommended to consult their general practitioner). * Conditions contraindicating the supplementation protocol. * Contraindications against nutritional or ergogenic supplements * Allergy/aversion against animal protein * Liver or kidney diseases with a non-permission to ingest certain concentrations of protein.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lean body mass (kg) | Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 20 minutes for all dxa-measurements | Lean body mass measured by dual-energy X-ray absorptiometry (DXA) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fat mass (kg) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements | Fat mass measured by dual-energy X-ray absorptiometry (DXA) |
| Resting energy expenditure (kcal pr. day) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - 15-25 minutes in total | Resting energy expenditure measured with the ventilated hood and indirect calorimetry |
| 1 Repetition maximum strength (kg) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all 1RM measurements | 1 repetition maximum strength in leg press, pull down and chest press |
| Maximal isometric knee extensor force (Nm) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements | Maximal isometric knee extensor force |
| Rate of force development (Nm/sec) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 25 minutes for all isokinetic dynamometer measurements | Unilateral rate of force development from onset of force until 0-30, 0-50, 0-100, 0-200ms of the knee extensor |
| Knee extensor power (W) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 15 minutes | Unilateral knee extensor power (W) |
| Sit to stand | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 3 minutes | 30 second sit to stand test |
| Full body bone mineral density (g/cm^2) | Pre (1 week prior to intervention) and post (1 week following intervention. i.e 14 weeks after inclusion) intervention - about 20 minutes for all dxa-measurements | Full body bone mineral density (BMD) (obtained by DEXA) |
| Blood sampling | Pre (1week prior to intervention) and post (1 week following intervention. i.e 14weeks after inclusion) intervention - about 3 minutes | Blood samples collected from the antecubital vein in a fasted state. Measurements of Hb1Ac, insulin, glucose, total cholesterol, high density lipoprotein, low density lipoprotein, triglycerides, HOMA-IR, Non-HDL cholesterol (Total - HDL), Total cholesterol / HDL ratio |
Countries
Denmark
Outcome results
None listed