Variation of Echocardiographic Parameters After Red Blood Cell Transfusion in Emergency Department Anemic Patients

Status

Recruiting

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06060639

Acronym

Trans-US

Enrollment

116

Registered

2023-09-29

Start date

2023-11-09

Completion date

2027-05-30

Last updated

2025-12-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Age Problem, Anemia, Ultrasonography

Brief summary

The goal of this interventional study is to asses echocardiographic variations in emergency department's elderly patients receiving red blood cell transfusion. The main questions it aims to answer are : * is there a modification of echocardiographic parameters after red blood cell transfusion ? * which parameter is the most impacted by red blood cell transfusion ? Participants will have a transthoracic echocardiography before, just after and 15 minutes after red blood cell transfusion.

Interventions

DIAGNOSTIC_TESTtransthoracic echocardiography

E wave, A wave, e' and vdi measurement

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* patient needing red blood cell transfusion * consent * social protection

Exclusion criteria

* fluid filing over 500 mL of crystalloids * transfusion in the last hour

Design outcomes

Primary

Measure	Time frame	Description
E/A ratio modification	Base line, just after and 15 minutes after red blood cell transfusion	E/A ratio permits to estimate left ventricle pressure

Secondary

Measure	Time frame	Description
E wave deceleration time	Base line, just after and 15 minutes after red blood cell transfusion	E wave deceleration time is a reflect of left atrium pressures
E/e' ratio modification	Base line, just after and 15 minutes after red blood cell transfusion	E/e' assesses left ventricle diastolic function
Velocity-time Integral (VTI) modification	Base line, just after and 15 minutes after red blood cell transfusion	Aortic velocity-time integral is the reflect of cardiac output
Lung score modification	Base line, just after and 15 minutes after red blood cell transfusion	Lung score permits to asses if extravascular water is present in lungs
New York Heart Association scale (NYHA) modification	baseline and 24 hour after red blood cells transfusion	NYHA is a validated scale to asses patient dyspnea

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026