Myocarditis, PVC - Premature Ventricular Contraction
Conditions
Brief summary
This prospective, observational study is a single center clinical registry of patients referred for management of symptomatic or asymptomatic Premature Ventricular Contractions (PVCs). Subjects will be followed through 12 months. The study will enroll approximately 50 patients.
Detailed description
This study is intended to monitor patients presenting with Premature Ventricular Contractions (PVCs) and ventricular arrhythmias using implantable loop recorders (ILRs) from the time of their initial presentation of PVCs to assess for the incidence of all cardiac arrhythmias detected with long term monitoring in this population. It is also intended to evaluate for clinical, biomarker and radiological evidence of myocarditis in this cohort to understand association with incident arrhythmias and understand the role of implantable loop recorders (ILRs)in managing these patients.
Interventions
OTHERMonitoring of patients presenting with PVCs
Patients presenting with PVCs and ventricular arrhythmias will be monitored using ILRs from the time of their initial presentation of PVCs to assess for the incidence of all cardiac arrhythmias. They will also be evaluated for clinical, biomarker and radiological evidence of myocarditis to understand association with incident arrhythmias.
Sponsors
Kansas City Heart Rhythm Research Foundation
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Patients \> 18 years of age * Have a Medtronic LINQ II ILR * Willing and able to give written informed consent
Exclusion criteria
* History of myocardial infarction * Significant flow-limiting coronary artery disease (≥50% stenosis) on invasive coronary angiography or Computed tomography angiography (CTA). * History of cardiac arrest * With existing implantable defibrillators * Currently pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Associated atrial and ventricular arrhythmias | 12 Months | Assessing incidence of associated atrial and ventricular arrhythmias as detected with ILR recordings in patients with apparently idiopathic PVCs. |
| Identification of unrecognized myocarditis | 12 Months | Identification of unrecognized myocarditis in patients presenting PVCs with positive FDG-PET \[fluorodeoxyglucose (FDG)-positron emission tomography (PET)\] scanning. |
| Evaluation of efficacy of immunosuppressive therapy - PVC burden reduce | 12 Months | Evaluation of efficacy of immunosuppressive therapy in patients with NICM with PVCs in reducing PVC burden as compared to their baseline PVC burden. |
| Evaluation of efficacy of immunosuppressive therapy - LVEF improvement | 12 Months | Evaluation of efficacy of immunosuppressive therapy in patients with NICM by documenting improvement in LVEF compared to their baseline LVEF. |
Countries
United States
Contacts
Primary ContactDonita Atkins
Outcome results
None listed