Ventilator Associated Pneumonia
Conditions
Brief summary
The aims of this study are to investigate the effect of eliminating routine GRV monitoring on VAEs in patients receiving MV and early EF, Determine the effect of eliminating routine GRV monitoring on nutritional adequacy in patients receiving MV and early EF and evaluate the effect of eliminating routine GRV monitoring on feeding intolerance in patients receiving enteral feeding.
Detailed description
Early enteral nutrition (EN) is consistently recommended as first line nutrition therapy in critically ill patients since it favorably alters outcome, providing both nutrition and non-nutrition benefits. However, critically ill patients receiving mechanical ventilation (MV) are at risk for regurgitation, pulmonary aspiration, and eventually ventilator-associated pneumonia (VAP). EN may increase these risks when gastrointestinal (GI) dysfunction is present. Gastric residual volume (GRV) is considered a surrogate parameter of GI dysfunction during the progression of enteral feeding in the early phase of critical illness and beyond. About 62% of critically ill patients receive enteral nutrition (EN) and in patients on MV, enteral feeding was connected to a threefold increase in the development of VAP. A new surveillance definition of ventilator-associated events (VAE) was introduced by the National Healthcare Safety Network (NHSN) in 2013 to identify patients who develop complications of MV. It outlines the various events in a step-by-step fashion, beginning with ventilator-associated complications (VAC), moving on to infectious complications (IVAC), and finally VAP. According to the NHSN, VAEs occur within 9% to 40% of mechanically ventilated patients
Interventions
PROCEDUREeliminating gastric residual volume monitoring
eliminating gastric residual volume monitoring from routine care
Sponsors
Damanhour University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
A parallel randomized controlled design will be used in this study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Adults (aged≥18 years) * Newly admitted mechanically ventilated patients who are attached to a mechanical ventilator for at least 48 hours. * Starting enteral nutrition via a nasogastric tube within 36 hours after intubation.
Exclusion criteria
* Abdominal surgery within the past month. * History of esophageal, duodenal, pancreatic, or gastric surgery. * Bleeding from the esophagus, stomach, or bowel. * Enteral nutrition via a jejunostomy or gastrostomy. * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| eliminating gastric residual volume monitoring on ventilator associated events | 3 month | use centers for disease control and prevention (CDC) calculators for evaluating VAE version 9.0 2021 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| eliminating gastric residual volume monitoring on nutritional adequacy | 3 month | evaluation daily caloric requirement by body mass index that calculated using the equation (Weight in kg /height in cm) 2 |
| eliminating gastric residual volume monitoring on incidence of feeding intolerance indicators | 3 month | evaluation of abdominal circumference, abdominal distension, bowel sounds, the episodes of vomiting and diarrhea |
Contacts
Primary ContactEnas Abdel sadek, Demonstrator
Backup ContactDr. Sahar Younes, Assistant Professor
Outcome results
None listed