Alzheimer Disease, Healthy, Lewy Body Disease
Conditions
Brief summary
The purpose of this research study is to investigate how the brain, memory, thinking, and motor behavior change both in individuals with movement and/or cognitive disorders, as well as healthy individuals. Researchers will look at measurements of memory, thinking, brain wave and muscle activity, daily functioning, and brain scans to learn more about brain disorders such as Alzheimer disease and Lewy body disease.
Interventions
DIAGNOSTIC_TESTMagnetic Resonance Imaging
Test that looks at the structure of the brain.
DIAGNOSTIC_TESTElectroencephalography
Non-invasive technique to measure brain waves
DIAGNOSTIC_TESTElectromyography
Technique to evaluate muscle activity
Sponsors
Mayo Clinic
National Institute on Aging (NIA)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Use English as their primary language. * Be willing to undergo health and cognitive assessments, as well as brain MRI and EEG study. * Will be encouraged to have an available study partner (also called a "co-participant") who is familiar with the participant's daily functioning. * This study will be limited to healthy individuals, and patients who have a clinical diagnosis made by a board-certified neurologist of Lewy body disease or Alzheimer disease. * All individuals must be capable of providing informed consent and complying with the trial procedures. Realizing the challenge of obtaining informed consent from cognitively impaired individuals, time is specifically scheduled to foster an informative, supportive interview with the participant and caregiver/legal guardian (typically a spouse or child according to Arizona law and IRB guidelines). * Ongoing participation will be maintained by strict adherence to inclusion/
Exclusion criteria
, clinical appropriateness (as determined by participant's physician and proxy/family), as well as by expressed wishes of family members/caregivers/proxy discussed at each study visit (as appropriate). * All participants will receive copies of the signed ICFs (including signatures of those obtaining consent). * All participants have the right to withdraw from the study at any time.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diffusion-weighted MRI (dMRI) | Baseline | Measures diffusion of water molecules and cellular-level constraints |
| Electroencephalography (EEG) | Baseline | Measures brain-wave activity |
Countries
United States
Contacts
CONTACTSara Dresler
PRINCIPAL_INVESTIGATORShannon Chiu, MD
Mayo Clinic
Outcome results
None listed