Facial Wrinkles - Rough Texture - Hyperpigmentation
Conditions
Brief summary
The aim of this work was to assess the efficacy of irradiated amniotic collagen matrix in comparison with platelet rich plasma in facial rejuvenation.The present study included 20 patients with facial wrinkles divided into 2 groups using split face technique: Group (A) subjected to microneedling with amnion gel on the right side of the face . Group (B) subjected to microneedling with PRP on the other side of the face.According to a skin analysis camera (antera camera), there was statistically significant improvement after treatment and between both groups as regard to the roughness(texture) and melanin appeared by Antera camera in which group (A) showed better improvement than group (B). Also, skin biopsies showed improvement in both sides after treatment in which the epidermis was thicker, collagen bundles were broader and thicker than before treatment also elastic fibers were longer, evenly arranged and thicker than before treatment. The patients were followed up over a period of 3 months after the last session with no complications or changes were occurred and the results of sessions were maintained.
Interventions
BIOLOGICALAmnion collagen
A collagen extract sourced from the human amniotic membrane
BIOLOGICALPlatelet-rich plasma
Autologous preparation of PRP
Sponsors
Waleed Nemr,Egyptian Atomic Energy Authority
Egyptian Atomic Energy Authority
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
36 Years to 57 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who did not receive any treatment for aging within the last 6 months. * Patients who accepted to participate in this study.
Exclusion criteria
* Patients with bleeding, coagulation disorders, severe anemia, liver disease, renal disease, recurrent facial herpes, keloid formation, pregnant, and lactating females.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of facial wrinkles according to wrinkle severity rate scale (WSRS) | 2 weeks | grade 0 = no wrinkles, grade I = just perceptible wrinkle, grade II = shallow wrinkles, grade III = moderately deep wrinkles, grade IV = deep wrinkle with well-defined edges, grade V = very deep wrinkle with redundant fold. |
| Evaluation of facial wrinkles according to Global Aesthetic Improvement Scale (GAIS) | 2 weeks | No improvement or mild improvement less than 25% moderate improvement = 26%-50% marked improvement = 51%-75% excellent improvement = more than 75% |
| skin pigmentation assessed by skin hyper-pigmentation index | 2 weeks | score: No pigmentation=1, sever pigmentation=4 |
| Histopathology improvement of skin biopsy | 2 weeks | improved skin structure=1, non-improved skin structure=0 |
Countries
Egypt
Outcome results
None listed