Chronic Total Occlusion of Coronary Artery, Diabetes Mellitus, Type 2
Conditions
Keywords
Atherosclerosis, Diabetes Mellitus, Type 2, Chronic Total Occlusion of Coronary Artery, Coronary artery disease
Brief summary
A severe coronary artery obstruction is a prerequisite for spontaneous collateral recruitment. The formation of coronary collateral circulation(CCC) is significantly impaired in type 2 diabetic patients with chronic total occlusion (CTO) compared with non-diabetic patients with CTO. This retrospective cohort enrolls consecutive T2DM patients who had at least one lesion with coronary angiographic total occlusion.
Detailed description
COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion (COLLECT) study is a single center, retrospective cohort study to investigate potential factors associated with the development of coronary collateral circulation in diabetic patients. Investigators will consecutively enroll T2DM patients who had at least one lesion with coronary angiographic total occlusion. The development of coronary collateral circulation will be graded according to the Rentrop method and patients will be divided into poor CCC (grade 0 or 1) or good (grade 2 or 3) CCC groups according to their Rentrop grades. Baseline clinical and laboratory characteristics at hospital admission will be recorded to analyze potential factors associated with the development of coronary collateral circulation in T2DM patients with CTO. Later, their cardiac function will be evaluated by echocardiography at one year follow-up.
Interventions
OTHEREchocardiography
Cardiac function was evaluated by echocardiography at one year follow-up.
Sponsors
Ruijin Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-90 years * Type 2 diabetes diagnosed by one of the following criteria: HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents. * At least one lesion with angiographic total occlusion
Exclusion criteria
* eGFR\<15mL/(min·1.73m2) * chronic heart failure with NYHA grade ≥3 * had a history of coronary artery bypass grafting * had received a percutaneous coronary intervention within the prior 3 months * Malignant tumor or immune system disorders * Pulmonary heart disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiac function evaluated by echocardiography | 12 months | Assessed by echocardiography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cardiovascular events | up to 5 years | The incidence of MACCE (major adverse cardiac and cerebrovascular events) |
Countries
China
Contacts
Primary ContactYing Shen, PhD
Backup ContactLinshuang Mao
Outcome results
None listed