Usage of High Flow Nasal Cannula in Preventing Desaturations in Elderly Patients Going for Lower Limb Surgeries

Comparing Intraoperative High Flow Nasal Cannula Therapy and Convetional Oxygen Therapy in Preventing Perioperative Hypoxaemia In Elderly Patients Undergoing Orthopaedic Surgery: A Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06054022

Enrollment

Registered

2023-09-26

Start date

2020-07-07

Completion date

2021-12-31

Last updated

2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atelectasis, Hypoxemia During Surgery

Keywords

high flow nasal cannula, elderly, orthopaedic, hypoxaemia, regional anaesthesia

Brief summary

To study the effect of high flow nasal cannula in comparisons with nasoprong used intraoperatively in patients oxygenation status

Detailed description

To observe the effect of high flow nasal cannula used intraoperatively compared to normal oxygen therapy (nasoprong) at a same fraction of inspired oxygen (FiO2) in elderly patients who are going for orthopaedic surgeries under central neuraxial block. oxygenation will be access with intermittent blood gas. atelectasis will be access via chest x-ray , compared to a baseline chest x-ray, validated by a blinded radiologist

Interventions

DEVICEhigh flow nasal cannula

high flow nasal cannula provides heated and humidified gas to the airways via nasal prongs at a prescribed accurate fraction of inspired oxygen (FiO2) ranging from 0.21 to 1.0 and with a higher flow rate of up to 60 litres per minute

DEVICEnasoprong oxyen 2Litres per minute

nasoprong @L/min will deliver approximately a FiO2 of 0.3. subsequently, if incremental O2 is needed, patient will be provided with ventimask 40% and so forth

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Masking description

there will be no masking except for the radiologist who compares the postoperative chest x-ray with the baseline

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

1. American Society of Anesthesiologists (ASA) I, II or III patients. 2. Patients age 60 years and above 3. Patients scheduled for total knee replacement therapy and hip surgeries under central neuraxial block under the elective and emergency list.

Exclusion criteria

1. Patients with pre-operative spO2\<94% 2. Patients delirious or demented / unable to give consent. 3. Patients with pre-existing pneumonia (defined as the initiation of antibiotics for suspected infection with one or more of the following: new or changed sputum; new or changed lung opacities; fever; white blood cell count \>12 × 109 litre-1 )15 4. BMI ≥35

Design outcomes

Primary

Measure	Time frame	Description
Incident of intraoperative desaturation	From induction time until end of surgery	desaturation is taken as any spO2 \<94%
Patient comfort on high flow nasal cannula	At end of surgery till discharge to ward (recovery area)	Patient rate comfort level using Visual Numerical Scale. The scale of 1 to 5 with 1 being extreme discomfort, 3 neutral and 5 extreme comfort
Atelactasis	From end of operation until 24 hours post surgery	Incident of postoperative atelectasis by compraring the preoperative and postoperative chest x ray by a radiologist

Secondary

Measure	Time frame	Description
Length of hospital stay	Time of hospital admission to time of discharge up to 30 days which ever come first	Duration of hospital admission from the time of patient admitted to the hospital, until discharge from hospital

Countries

Malaysia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026