Hypertensive Disorders of Pregnancy
Conditions
Brief summary
The goal of this study is to evaluate the use of aspirin for the prevention of preeclampsia among moderate -to- high-risk pregnant women in tertiary care hospitals in Nigeria followed by a qualitative study to evaluate the barriers and facilitators of aspirin use in prenatal care for the prevention of preeclampsia in Nigeria. The main question\[s\] it aims to answer are: 1. Is Aspirin used for the prevention of preeclampsia among pregnant women in Nigeria? 2. What factors promote or prevent the utilization of Aspirin for preeclampsia prevention among pregnant women in Nigeria.
Detailed description
Nigeria has the highest burden of maternal mortality worldwide accounting for over 1 in 4 of global maternal deaths. In a 2022 nationwide analysis of maternal outcomes in 76,563 deliveries across referral-level hospitals in Nigeria, hypertensive disorders of pregnancy (HDP) including preeclampsia accounted for 32% of maternal deaths. Studies have linked the pathophysiology of preeclampsia to peripartum cardiomyopathy (PPCM) which is prevalent in Nigeria.5,6 Patients with PPCM were 4 times as likely to have preeclampsia that patients without PPCM. Among known evidence-based interventions for HDP, aspirin prophylaxis stands out as among the most highly effective in preeclampsia prevention. A comprehensive understanding of utilization patterns, or lack thereof, as well as the identification of barriers and facilitators, can inform implementation studies aimed at increasing adoption of this highly effective and cost-effective intervention. Aims: 1. To conduct a multisite cross-sectional study to evaluate the utilization of aspirin use for the prevention of preeclampsia amongst moderate- to high-risk pregnant women in tertiary care hospitals in Nigeria. We hypothesize that there is underutilization of aspirin for the prevention of preeclampsia amongst pregnant women at moderate- to high-risk of preeclampsia in Nigeria. 2. To conduct a qualitative research study to evaluate facilitators and barriers to aspirin use in prenatal care for prevention of preeclampsia in Nigeria. We hypothesize that there is underutilization of aspirin for the prevention of preeclampsia amongst pregnant women at moderate- to high- risk of preeclampsia in Nigeria.
Interventions
OTHERExposure of interest - Moderate or High-risk Preeclampsia
No intervention
Sponsors
University of Abuja Teaching Hospital
Aminu Kano Teaching Hospital
Murtala Muhammad Specialist Hospital
National Hospital, Abuja
Washington University School of Medicine
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Adult pregnant woman \> 18 years old / emancipated pregnant minors (\<18years), according to the stipulations of the Nigerian National Health Research Ethics Committee (NRHEC) * \>12 weeks' gestation attending antenatal care clinics on 2nd or subsequent visit * Those presenting to the labor and delivery room.
Exclusion criteria
* Unable to provide consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aspirin Use Proportion | 12 weeks- 42 weeks gestation | Proportion of women (participants) at moderate- or high-risk of preeclampsia who report aspirin use. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Moderate or High-risk Preeclampsia Proportion. | Throughout study duration, from 2nd antenatal visit or after 12 weeks' gestation | Proportion of women at moderate- to high-risk of preeclampsia among those attending antenatal care who are participants. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Preeclampsia or Eclampsia proportion categorized as moderate or high risk | Throughout study duration, from 2nd antenatal visit or after 12 weeks' gestation | Proportion of women presenting with preeclampsia or eclampsia at delivery who would have been categorized as moderate or high- risk at antenatal care visits out of the entire cohort of pregnant participants. |
Countries
Nigeria
Outcome results
None listed