Acute Appendicitis
Conditions
Brief summary
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.
Interventions
DIAGNOSTIC_TESTBlood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels
Blood analysis of CRP and WBC levels Saliva analysis of CRP levels
Sponsors
University Hospital of Split
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 17 Years
Inclusion criteria
* children with age from 5 to 17 with acute abdominal pain * children with clinical signs of appendicitis
Exclusion criteria
* previous diagnosis of chronic and/or malignant disease * children wich had previous abdominal surgery * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of CRP in blood | 72 hours | Levels of CRP in blood as measured by ELISA test |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Level of CRP in saliva | 72 hours | Levels of CRP in saliva as measured by ELISA test |
Contacts
Primary ContactKlaudio Pjer MD Milunovic
Outcome results
None listed