Pediatric Acute Respiratory Distress Syndrome (PARDS), Acute Respiratory Failure, Acute Respiratory Distress Syndrome
Conditions
Keywords
Acute respiratory failure (ARF), esophageal catheter, transpulmonary pressure
Brief summary
Mechanical ventilation is a critical intervention in the management of pediatric patients with respiratory distress. During this process, accurate measurement of transpulmonary pressure (PL) is essential to ensure the safety and efficacy of ventilation. PL is defined as the difference between alveolar pressure (Palv) and pleural pressure (Ppl). While the direct measurement of Ppl is possible, it poses a risk to tissue integrity. Thus, the primary surrogate for Ppl measurement today is esophageal pressure (Pes). However, the measurement of Pes is not without challenges. This abstract outlines the pitfalls associated with Pes measurement, emphasizing the importance of employing well-defined procedures to mitigate potential errors. These errors can range from underestimation of Pes due to underfilled catheters to overestimation resulting from overfilled catheters. To address these challenges and optimize Pes measurement, various methods have been proposed for titrating the filling volume of the esophageal catheter. In this study, investigators aim to assess a faster decremental filling method and compare it to the traditionally accepted Mojoli method in the context of pediatric patients. This research seeks to enhance the intensivists' understanding of the most efficient and accurate approach to Pes measurement during mechanical ventilation in the pediatric population, ultimately contributing to improved patient care and outcomes
Interventions
OTHERFast method
Fast decremental catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
OTHERConventional method
Conventional catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Sponsors
Dr. Behcet Uz Children's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Months to 18 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric patients between 1 months and 18 years * Patients need mechanical ventilation support without modification of ventilation settings within the upcoming 2 hours * Informed consent was signed by next of kin * Requiring esophageal catheter application
Exclusion criteria
* Patients eligible for extubation or modification of ventilation settings within the upcoming 2 hours * Patient included in another interventional study in the last 30 days * Patients unable to undergo esophageal catheter insertion due to congenital or acquired pathologies * Patient included in another interventional research study under consent * Patient already enrolled in the present study in a previous episode of acute respiratory failure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Optimal catheter filling volume | up 1 hour after catheter placement | The clinician will determine the optimal filling volume of the catheter using two distinct methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Transpulmonary driving pressure | up 1 hour after catheter placement | The measured transpulmonary driving pressure achieved using the optimal filling volume of the catheter |
| Time | up 1 hour after catheter placement | The duration necessary to ascertain the optimal filling volume of the esophageal catheter |
Countries
Turkey (Türkiye)
Contacts
Primary ContactHasan Agin, Professor
Backup ContactGokhan Ceylan, Associate Professor
Outcome results
None listed