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Mechanisms of Exercise-Induced Hypoalgesia

Mechanisms of Exercise-Induced Hypoalgesia

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06050889
Enrollment
60
Registered
2023-09-22
Start date
2023-11-14
Completion date
2024-04-19
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

Exercise-Induced Hypoalgesia (EIH) is a lessening of pain sensitivity in response to an acute bout of exercise. Limited research has examined the effects of expectations on EIH during a dynamic resistance training during different intensities. Therefore, the purpose of this study is to examine the effects of positive and negative expectations on EIH.

Detailed description

Individuals who meet the eligibility criteria and consent to participate will attend one testing session that is approximately one hour. Baseline Pressure Pain Threshold will be measured followed by random assignment to one of four study arms.

Interventions

OTHERPositive Expectations Instructional Set

Participants randomly assigned to this instructional set will be told, You will be completing an intervention known to be effective for some people with shoulder pain. We expect this will make you less sensitive to the pressure applied to your shoulder and thigh and you will require more pressure than what was previously necessary to experience pain.

OTHERNegative Expectations Instructional Set

Participants randomly assigned to this instructional set will be told, You will be completing an intervention which is not effective for some people with shoulder pain. We expect this will make you more sensitive to the pressure applied to your shoulder and thigh and you will require less pressure than what was previously necessary to experience pain.

Sponsors

University of Central Florida
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Pain Free

Exclusion criteria

* Non-English speaking * Regular use of prescription pain medications * Current or history of chronic pain condition * Currently taking blood-thinning medication * Any blood clotting disorder, such as hemophilia * Systemic medical condition known to affect sensation, such as uncontrolled diabetes or neurological conditions * Not physically ready to exercise without a medical exam as indicated by the Physical Activity Readiness Questionnaire Plus (PAR-Q+) * Not have had Surgery, injury, or fracture within the past 6 months

Design outcomes

Primary

MeasureTime frameDescription
Pressure Pain ThresholdChange from baseline immediately after exercisePressure Pain Threshold will be applied with a digital algometer before and after the exercise intervention.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026