Gilles de la Tourette Syndrome, OCD, Tic Disorders
Conditions
Keywords
Electrophysiology, Electroencephalogram, EEG, Accelerometer, Biomarker, Symptom provocation
Brief summary
Introduction: Repetitive behaviors (RB) constitute a broad range of symptoms across different psychiatric/neurologic disorders. The most famous are stereotypies (found in autism), compulsions (found in obsessive-compulsive-disorder, OCD) and tics (found in Gilles de la Tourette syndrome, GTS). For some patients, it is sometime difficult to distinguish the nature of the repetitive behaviors presented, however this distinction is crucial in order to chose the appropriate treatment. Aim: In our study, the investigators will try to define electrophysiological and accelerometric marker of both OCD and tics to allow objective distinction between both tics and compulsions. Method: Subjects: Both OCD and GTS patients will be recruited, 25 patients in each group. Protocol: our study protocol will involve two step: a step in laboratory, another step at patient home. * first step: both patients group will be recorded through a high density EEG and a portative EEG while doing a task of symptom provocation. Then they will get an anatomical MRI for source recontruction. Finally, the patients will have to mimic their symptom while wearing an accelerometer (a smartwatch). * second step: both patient groups will be recorded at home through a portative EEG while tagging their symptom through a smartwatch (also used for accelerometry). After the recording, the patients will keep the smartwatch for 2 weeks, still tagging their sympoms (compulsions or tics).
Interventions
DEVICEEEG
Recording, from the scalp, the electrophysiological activity of the brain.
DEVICEMRI
Get the anatomical shape of the brain.
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
15 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* To be more of 15 years old or less than 65 years old * To suffer from OCD and/or GTS (depressive, anxious and attention deficit hyperactivity disorder (ADHD) comorbidities are accepted) * To be registered to the french social security (or something equivalent) * To give written consent to participate to the research * To have contraception for women participants (or to not have any sexual activity)
Exclusion criteria
* Patients with any other psychiatric disorders than those mentioned in the inclusion criteria * Patients with any other neurological disorder than GTS * Patients who are not able to take decisions for themselves * Pregnant women * Patients not allowed to get MRI due to contraindication * Patients not speaking french
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| modification of power (μV2) in EEG frequencies before compulsions in Obsessive-Compulsive Disorder patients | one year | change in the power EEG frequencies in OCD patients before compulsions EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations |
| modification of power (μV2) in EEG frequencies before tics in Gilles de la Tourette patients | one year | change in the power of EEG frequencies in GTS patients before tics EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in power (μV2) in EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients | One year and a half | Difference in the power in the EEG frequencies between obsessive-compulsive disorder patients and Gilles de la Tourette patients EEG frequencies come to 0 to 250 Hz, the power is the amplitude of oscillations |
| percentage (%) of compulsions and tics detected by accelerometer | One year and a half | percentage of compulsions and tics detected by accelerometer |
| Correlation of EEG frequency power (arbitrary units) detected before compulsions and scores get with clinical scales (Y-BOCS) | One year and a half | Correlation between power in EEG frequencies and Y-BOCS score get by each individual patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms |
| Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients | One year and a half | Correlation between number of compulsions detected by accelerometer and Y-BOCS scores get by obsessive-compulsive patients Y-BOCS = Yale-Brown Obsessive-Compulsive Scale; Scores range from 0 to 40 with 40 corresponding to the maximum severity of symptoms |
Countries
France
Contacts
CONTACTLuc MALLET, MD
CONTACTHugues LAMOTHE, MD
PRINCIPAL_INVESTIGATORLuc MALLET, MD
Assistance Publique - Hôpitaux de Paris
Outcome results
None listed