Periodontal Attachment Loss, Periodontal Diseases, Periodontal Inflammation, Periodontitis
Conditions
Brief summary
The scientific literature has verified that coconut oil has properties that open perspectives for its application in order to maintain oral health and, in particular, for the treatment of different oral pathologies. Thus, the purpose of this project is summarized in the following objectives: 1. Determine in vitro the biocompatibility of coconut oil. 2. Determine in vivo the clinical effect of coconut oil as an adjunct treatment for periodontal disease.
Detailed description
Periodontal disease is one of the most prevalent pathologies in humans. In the latest survey on Oral Health in Spain by the Council of Dentists of Spain, it is determined that between 85-94% of the Spanish population over 35 years of age has some problem related to their gums. Severe periodontal diseases, which can lead to tooth loss, affect 15%-20% of middle-aged adults (35-44 years). One of the most common products used as an antibacterial agent to treat different oral conditions is chlorhexidine and its derivatives. Chlorhexidine exists commercially in different preparations such as mouthwash, toothpaste and gel, among others. Their main drawbacks are that in the long term they stain the teeth and can cause oral lesions, burning sensation and a deterioration in the sensation of taste. Likewise, various antibiotics, both local and systemic, are used as an adjuvant in the treatment of certain types of gum diseases. Due to the rapid increase in bacterial resistance due to the extensive use of antibiotics, it is important to evaluate alternative antimicrobial agents that can help reduce the use of antibiotics. Both the coconut and the plant from which this fruit comes are widely used in traditional medicine. Furthermore, the scientific literature on the biological effect of different presentations of this plant (alcoholic extract of coconut shell, coconut water, coconut oil, etc.) has shown, among others, anti-inflammatory activities, analgesic, antioxidant, antifungal, antimicrobial and even antitumor. There are several hypotheses that suggest that the benefits of using coconut oil can be attributed to the presence of lauric acid, which has the ability to destroy the lipid membrane of microorganisms such as the herpes virus and Gram positive and Gram negative bacteria. Likewise, the viscosity of the oil could inhibit bacterial adhesion and plaque accumulation. Recent studies describe that oral rinses with coconut oil provide an inhibition in the accumulation of bacterial plaque and plaque-induced gingivitis and a significant reduction of Streptococcus mutans in saliva, suggesting that coconut oil can have a preventive therapeutic application, with fewer adverse effects and lower cost for the maintenance of oral health and treatment of various oral pathologies such as Gingivitis and Periodontitis. Therefore, the purpose of this study is to determine the effectiveness of coconut oil as an adjunct treatment for periodontal disease.
Interventions
DIETARY_SUPPLEMENTCoconut Oil
Coconut oil rinsing
DRUGChlorhexidine mouthwash
Chlorhexidine rinsing
OTHERWater mouthwash
Control with water rinsing
Sponsors
Universidade da Coruña
University Hospital A Coruña
Fundacion Clinica Pardinas
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients of legal age (18 years) affected by periodontitis with the ability to read, understand and sign the informed consent after having explained the nature of the study, with a willingness to follow protocol requirements * Diagnosed with periodontal disease stages II, III and IV and grades B and C * Minimum of 16 natural teeth
Exclusion criteria
* Patients who have been treated with antibiotics in the last 4 weeks and who are currently being treated with antibiotics. * Patients who regularly use gum or candies with xylitol, coconut or coconut derivatives. * Patients who have received dental cleaning within the last 6 months. * Pregnant and breastfeeding patients, * Patients with allergies to coconut, coconut-derived products and chlorhexidine * Patients with uncontrolled diabetes, uncontrolled high blood pressure, bleeding disorders, liver or kidney disease, heart disease, active cancer, active infectious diseases (other than periodontitis) and patients with a history of local irradiation therapy in the head/neck area.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Probing depth in mm | At 0 days, 30 days and 60 days | To evaluate the effect of treatment on probing depth reduction. |
| Volatile compounds in breath in ppm of sulphur compounds | At 0, 30 and 60 days | To evaluate the effect of treatment on the presence of sulphur compounds present on breath |
| Type of bacteria present on samples from saliva and crevicular fluid using Illumina SBS (Sequencing by synthesis) | At 0, 30 and 60 days | To evaluate the effect of treatment on the oral microbiome |
| Plaque index in percentage | At 0, 30 and 60 days | To evaluate the effect of treatment on reduction of plaque accumulation |
| Bleeding on probing in percentage | At 0 days, 30 days and 60 days | To evaluate the effect of treatment on reduction of bleeding on probing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Tooth color change measured with the VITA score | At 0, 30 and 60 days | To evaluate the change on tooth color before and after using the mouthwash. |
| Patient perception using Visual Analog Scale | At 0, 30 and 60 days | To evaluate patient perception on the use of the mouthrinse in a scale from 1 to 10 for each question. |
Countries
Spain
Outcome results
None listed