Diabetic Kidney Disease, Extracellular Matrix Alteration
Conditions
Keywords
Diabetic Kidney Disease, extracellular matrix, parietal epithelial cells
Brief summary
Diabetic kidney disease (DKD) is the leading cause for renal replacement therapy in developed country. DKD is also the primary cause of ESKD among middle-aged and elderly people in China. Renal pathological markers have been proved to have clinical and prognostic value in both non diabetic and diabetic kidney diseases. To discriminate lesions by various degrees of severity, the Working Group of the Renal Pathology Society (RPS) developed a pathologic classification for DKD in 2010. The classification is based on glomerular lesions, with a separate evaluation for interstitial and vascular lesions. In a decade, there were several new characteristics common to DKD, such as the presence of mesangiolysis, glomerular hyalinosis, segmental sclerosis and extracapillary hypercellularity, which have been noted in patients with diabetes and may have prognostic importance. But it is still unclear whether thickening of Bowman's capsule predicts the progression of DKD.
Interventions
OTHERno intervention
no intervention
Sponsors
RenJi Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* 1\) Age ≥ 18 years old, male or female 2) Patients diagnosed as diabetes kidney disease by renal biopsy
Exclusion criteria
* 1\) Patients combined with non diabetes kidney disease; 2) Patients with kidney transplant failure; 3) Patients undergoing zero point puncture for kidney transplantation; 4) less than 5 glomeruli in the renal puncture sample.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal failure | From the diagnosis of diabetes kidney disease by renal biopsy to December 31, 2022 | estimated glomerular filtration rate（eGFR）\<15ml/min/1.73m2, renal replacement treatment or death caused by renal disease |
Contacts
Primary ContactJiayue Lu
Outcome results
None listed