FMF
Conditions
Brief summary
The aim of this study is to search for subclinical atherosclerosis in children diagnosed as FMF in Assiut University children's Hospital, and to correlate the risk to develop atherosclerosis to the different characters and genetic variants of FMF.
Detailed description
* To describe the clinical characteristics of patients diagnosed as FMF in Upper Egypt, and to find the most common presenting symptoms. * To mention the most common genetic variants reported in FMF patients in Upper Egypt, and to correlate the genetic variant with the risk to develop atherosclerosis. * To assess the growth parameters in patients with FMF and compare it with the control group. * To estimate the differences in Complete blood count (CBC) parameters, lipid profile, CIT in patients with FMF and control group. * To search for subclinical atherosclerosis in patients with FMF based on their lipid profile and CIT.
Interventions
RADIATIONultrasound on carotid
CIT will be assessed using ultrasound evaluation by measuring the intima-media thickness of carotid arteries (IMT). This non-invasive method is used to detect subclinical atherosclerosis and it can be used in a multitude of patients including children\[11\]. It will be carried out on the two study groups (FMF patients and the control group) and the results will be compared. It will be conducted in Assiut University Neurosonology Unit, at the Department of Neurology.
Sponsors
Assiut University
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
1 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age at enrollment less than18 years. 2. Both sexes. 3. Diagnosed as familial Mediterranean fever according to Tel Hashomer criteria. \[10\]
Exclusion criteria
1. Patients with acute or chronic active infections. 2. Patients with pre-existing illness as chronic lung, liver or renal diseases. 3. Patients with diabetes mellitus, atherosclerotic vascular disease. 4. Patients with malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| detecting subclinical atheroscelerosis | It will be measured in one year | The aim of this study is to detect subclinical atherosclerosis in children diagnosed as FMF in Assiut University children's Hospital by measuring carotid intima thickness |
Contacts
Primary ContactAli Abdelhaleem Hussein, bachelor
Backup ContactNaglaa mohamed samy, lecturer
Outcome results
None listed