Atherosclerosis
Conditions
Brief summary
Mainly studying the correlation between the abundance of Prevotella copri （P.copri） in the gut microbiome and the progression of clinical coronary atherosclerotic heart disease（CAD） patients, and confirming that an increase in P.copri abundance will accelerate the occurrence and development of CAD disease, accompanied by an increase in serum Branched chain amino acid（BCAA）, lipopolysaccharide（LPS）, and serotonin; For people who mainly consume a high carbon water diet, blood sugar is a stronger risk factor for AS compared to blood lipids; Explore the KAP status（Study composes of Knowledge, attitude, and practice） of coronary heart disease patients and their caregivers regarding coronary heart disease and diet, and investigate whether the popularization of science after KAP investigation can change the treatment effect of patients.
Detailed description
Confirming the progression of coronary heart disease in patients and the proportion of P.copri in the gut microbiome; Confirming that due to the increased abundance of P.copri, factors related to blood glucose metabolism disorders are more associated with the progression of CAD disease compared to lipid factors; Confirming that P.copri induces insulin resistance and inflammation in the body while altering intestinal permeability through the synthesis of BCAA, LPS, and serotonin;; Through controlled experiments conducted at our center, investigators effectively popularized disease science to patients and their caregivers, promoted their participation in disease treatment, and confirmed that the KAP survey method can optimize patient treatment effectiveness, improve doctor-patient relationships, and enhance patient hospitalization experience. Through this research project, investigators explore the application of KAP research in the form of a questionnaire in this discipline. Through KAP research, investigators aim to popularize knowledge about dietary patterns and coronary heart disease among multi center coronary heart disease patients and their caregivers. investigators also investigate the knowledge, belief, and behavior of current coronary heart disease patients and their caregivers regarding coronary heart disease diagnosis and treatment knowledge, and conduct a knowledge lecture, Establish a new model for mastering, attitudes, and actions related to the diagnosis and treatment of coronary heart disease among patients and their accompanying caregivers through data push and other forms, while also providing theoretical and practical basis for subsequent related research. Through this project, investigators will discuss the feasibility of KAP survey in increasing patients' subjective initiative, improving doctor-patient relationships, and promoting the effectiveness of patient treatment. investigators will also discuss its promotion and inclusion in routine diagnostic and treatment methods.
Interventions
BEHAVIORALKAP Popular Science Research
By conducting a survey questionnaire, investigate the knowledge, attitude, and practice tendencies of patients and their caregivers towards a certain disease, and conduct relevant science popularization；Pre discharge satisfaction survey questionnaire
BEHAVIORALNo KAP Popular Science Research
Pre discharge satisfaction survey questionnaire
Sponsors
Hai Tian
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
ALL
Age
50 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Atherosclerosis mechanism research: diagnosis is made through clinical diagnostic technical indicators, mainly coronary CT or coronary angiography. Experimental group: patients with coronary heart disease are identified; Control group: Admitted patients without coronary heart disease but may have other heart diseases or risk factors; Age:\>50 years old 2. KAP Study: Coronary Heart Disease Patients and Their Families
Exclusion criteria
1. Atherosclerosis mechanism research: age\<50 years old; Patients with a history of coronary heart disease or surgery; Patients with systemic diseases, including liver and kidney diseases (with serum creatinine levels\>2mg/dL (176.8 μ Mol/dL), collagen diseases, etc; Patients who have been using antibiotics within the past 6 months; Patients with malignant tumor disease 2. KAP Study: Non coronary heart disease patients and their caregivers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pulmonary artery pressure | 7 days before surgery | Ultrasonic instrument exploration |
| Concentration of Brain Natriuretic Peptide | Within 7 days after surgery | Blood sampling and testing |
| Concentration of myocardial enzyme | Within 7 days after surgery | Blood sampling and testing |
| Concentration of troponin | Within 7 days after surgery | Blood sampling and testing |
| questionnaire1 | Within 7 days after admission | KAP scale，This questionnaire consists of a total of 25 questions, with the first 7 questions being the baseline survey of the subjects, which facilitates statistical information without involving scores. The remaining questions consist of 10 knowledge questions (each desired response was scored 1, maximum K-score was 10), 5 attitude questions (each desired response was scored 1, maximum A-score was 5), and 3 practice questions (this question consists of 5 options, depending on frequency or severity, 1 is obtained when selecting 1 or 2 options, 2 is obtained when selecting 3 options, 3 is obtained when selecting 4 or 5 options, and 5 is obtained when selecting maximum P-score was 5)，higher scores mean a better outcome |
| questionnaire2 | Within 7 days after surgery | Composed of 5 questions, choose the expected answer and add 1 point. The higher the score, the better |
| Prevotella copri abundance | through study completion, an average of 1 year | 16S ribosomal DNA identification sequencing of feces |
| Concentration of branched chain amino acids | through study completion, an average of 1 year | Blood sampling and testing |
| Concentration of serotonin | through study completion, an average of 1 year | Blood sampling and testing |
| lipopolysaccharides | through study completion, an average of 1 year | Blood sampling and testing |
| Concentration of blood glucose | through study completion, an average of 1 year | Blood sampling and testing |
| Concentration of lipids | through study completion, an average of 1 year | Blood sampling and testing |
| cardiac ejection fraction | Within 7 days after surgery | Ultrasonic instrument exploration |
| ejection volume | 7 days before surgery | Ultrasonic instrument exploration |
| left ventricular size | Within 7 days after surgery | Ultrasonic instrument exploration |
| end diastolic diameter | 7 days before surgery | Ultrasonic instrument exploration |
| left ventricular end systolic diameter | Within 7 days after surgery | Ultrasonic instrument exploration |
Countries
China
Outcome results
None listed